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Clinical effects of...
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Dobre, Daniela
(författare)
Clinical effects of initial 6 months monotherapy with bisoprolol versus enalapril in the treatment of patients with mild to moderate chronic heart failure. Data from the CIBIS III trial
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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2008-06-05
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Springer Science and Business Media LLC,2008
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LIBRIS-ID:oai:lup.lub.lu.se:69b7e4ab-dd25-4609-a3ff-18792ed8d62e
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https://lup.lub.lu.se/record/1247303URI
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https://doi.org/10.1007/s10557-008-6116-9DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Purpose To assess the clinical effects and safety profile of initial monotherapy with either bisoprolol or enalapril in elderly patients with heart failure (HF). Methods In CIBIS III, 1010 patients with mild to moderate HF and age >= 65 years were randomized to monotherapy with either bisoprolol or enalapril for 6 months. Results Bisoprolol had a similar effect as enalapril on the combined end-point of all-cause mortality or hospitalization (HR 1.02; p=0.90), as well as on each of the individual end-points. A trend towards fewer sudden deaths was observed with bisoprolol (NS). On the other hand, more cases of worsening HF requiring hospitalization or occurring while in hospital were observed in the bisoprolol group (HR 1.67; p=0.03). The two groups were similar with regard to treatment cessations and early introduction of the second drug. Conclusions Bisoprolol and enalapril had a similar effect on the combined end-point of mortality or hospitalization during 6 months monotherapy. However, more worsening HF events were observed in the bisoprolol group.
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van Veldhuisen, Dirk J.
(författare)
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Goulder, Michael A.
(författare)
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Krum, Henry
(författare)
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Willenheimer, RonnieLund University,Lunds universitet,Kardiologiska klinikens forskargrupp,Forskargrupper vid Lunds universitet,Cardiology Research Group,Lund University Research Groups(Swepub:lu)medf-rw0
(författare)
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Kardiologiska klinikens forskargruppForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cardiovascular Drugs and Therapy: Springer Science and Business Media LLC22:5, s. 399-4050920-32061573-7241
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