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Sökning: WFRF:(Hogendoorn Pancras C. W.) > (2019) > Quality of life of ...

  • Calaminus, GabrieleUniversity Hospital Bonn (författare)

Quality of life of patients with osteosarcoma in the european american osteosarcoma study-1 (EURAMOS-1) : Development and implementation of a questionnaire substudy

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-09-26
  • JMIR Publications Inc.2019

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:69e01d59-f149-41cc-9b5c-d9f0b7091271
  • https://lup.lub.lu.se/record/69e01d59-f149-41cc-9b5c-d9f0b7091271URI
  • https://doi.org/10.2196/14406DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: The quality of life (QoL) of patients with osteosarcoma (OS) may be adversely affected by the disease or its treatment. Therefore, it is important to understand the QoL of patients undergoing treatment for OS to improve the QoL. We report on the first prospective international QoL study that was embedded within a large randomized clinical trial from 4 national study groups. Objective: This paper aimed to describe the QoL study development, methodology, accrual details, and characteristics of the QoL cohort. Methods: A total of 2260 patients registered in the EURopean AMerican Osteosarcoma Study-1 (EURAMOS-1), of whom 97.92% (2213/2260) were eligible for the optional QoL assessment and could participate in terms of questionnaire availability. Overall, 61.86% (1369/2213) of patients and/or proxies completed the QoL evaluation at the first assessment time point (E1) after the start of preoperative treatment. The QoL measures used (self- and/or proxy reports) depending on the patient’s age and national study group. Participants and nonparticipants in the ancillary QoL study were compared regarding relevant demographic and disease-related characteristics at registration in the trial. Results: The participation rate at time point E1 did not differ with regard to age, gender, the occurrence of pathological fracture, or the presence of any metastases at diagnosis. No differences were found regarding the primary tumor site. Only the national study group affiliation had an influence on participation. Participation decreased linearly with trial progress up to 20% at the final time point of QoL assessment. Conclusions: This study demonstrates the feasibility of international cooperation for the purpose of assessing and understanding the QoL of pediatric and adolescent/young adult patients with cancer. Future outcomes of this QoL substudy will help to adapt interventions to improve QoL.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jenney, MerielUniversity Hospital of Wales (författare)
  • Hjorth, LarsLund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-lhj (författare)
  • Baust, KatjaUniversity Hospital Bonn (författare)
  • Bernstein, MarkDalhousie University (författare)
  • Bielack, StefanKlinikum Stuttgart Olgahospital (författare)
  • de Vos, PatriciaGhent University Hospital (författare)
  • Hogendoorn, Pancras C.W.Leiden University Medical Centre (författare)
  • Jovic, GordanaUniversity College London (författare)
  • Krailo, MarkUniversity of Southern California,Children's Oncology Group, Arcadia (författare)
  • Kreitz, KianaUniversity of Münster (författare)
  • Marina, NeyssaFive Prime Therapeutics Inc (författare)
  • Popoola, Babasola O.University College London (författare)
  • Sauerland, CristinaUniversity of Münster (författare)
  • Smeland, SigbjørnUniversity of Oslo,Oslo university hospital (författare)
  • Teske, CarmenUniversity Hospital Bonn (författare)
  • Schweinitz, Clara V.University Hospital Bonn (författare)
  • Whelan, JeremyUniversity College London Hospital (författare)
  • Wiener, AndreasWest German Proton Therapy Centre Essen (WPE) (författare)
  • Sydes, Matthew R.University College London (författare)
  • Nagarajan, RajaramUniversity of Cincinnati,Cincinnati Children's Hospital Medical Center (författare)
  • University Hospital BonnUniversity Hospital of Wales (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:JMIR Research Protocols: JMIR Publications Inc.8:91929-0748

Internetlänk

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