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A bacterial protease depletes c-MYC and increases survival in mouse models of bladder and colon cancer
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- Butler, Daniel S.C. (author)
- Lund University,Lunds universitet,Cancerinfektion,Forskargrupper vid Lunds universitet,Cancer Infection,Lund University Research Groups
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- Cafaro, Caterina (author)
- Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Putze, Johannes (author)
- University of Münster
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- (creator_code:org_t)
- 2021-02-11
- 2021
- English 11 s.
- In: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 39:6, s. 754-764
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Is the oncogene MYC upregulated or hyperactive? In the majority of human cancers, finding agents that target c-MYC has proved difficult. Here we report specific bacterial effector molecules that inhibit cellular MYC (c-MYC) in human cells. We show that uropathogenic Escherichia coli (UPEC) degrade the c-MYC protein and attenuate MYC expression in both human cells and animal tissues. c-MYC protein was rapidly degraded by both cell-free bacterial lysates and the purified bacterial protease Lon. In mice, intravesical or peroral delivery of Lon protease delayed tumor progression and increased survival in MYC-dependent bladder and colon cancer models, respectively. These results suggest that bacteria have evolved strategies to control c-MYC tissue levels in the host and that the Lon protease shows promise for therapeutic targeting of c-MYC in cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
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- Tran, Thi Hien
- Ambite, Ines
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- Ahmadi, Shahram
- Kjellström, Sven
- Welinder, Charlo ...
- Chao, Sing Ming
- Dobrindt, Ulrich
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