The estimated effect of season and vitamin D in the first trimester on pubertal timing in girls and boys : A cohort study and an instrumental variable analysis

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Gaml-Sørensen, AnneUniversity of California, Los Angeles,Aarhus University (author)

The estimated effect of season and vitamin D in the first trimester on pubertal timing in girls and boys : A cohort study and an instrumental variable analysis

Article/chapterEnglish2023

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2023
13 s.

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LIBRIS-ID:oai:lup.lub.lu.se:6a0d9e42-7ddf-4cb1-a716-249f7be5ee5a
https://lup.lub.lu.se/record/6a0d9e42-7ddf-4cb1-a716-249f7be5ee5aURI
https://doi.org/10.1093/ije/dyad060DOI

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Language:English
Summary in:English

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Background: Season of birth has been associated with age at menarche. Maternal vitamin D levels in pregnancy may explain this effect. We investigated whether the season of first trimester or maternal 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with pubertal timing in children. Methods: We conducted a follow-up study of 15 819 children born in 2000-03 from the Puberty Cohort, nested in the Danish National Birth Cohort (DNBC). Mean differences in attaining numerous pubertal markers, including a combined estimate for the average age at attaining all pubertal markers, were estimated for low (November-April) relative to high (May-October) sunshine exposure season in the first trimester using multivariable interval-censored regression models. Moreover, we conducted a two-sample instrumental variable analysis using season as an instrument for maternal first-Trimester 25(OH)D3 plasma levels obtained from a non-overlapping subset (n = 827) in the DNBC. Results: For the combined estimate, girls and boys of mothers who had their first trimester during November-April had earlier pubertal timing than girls and boys of mothers whose first trimester occurred during May-October:-1.0 months (95% CI:-1.7 to-0.3) and-0.7 months (95% CI:-1.4 to-0.1), respectively. In the instrumental variable analysis, girls and boys also had earlier pubertal timing: respectively,-1.3 months (95% CI:-2.1 to-0.4) and-1.0 months (95% CI:-1.8 to-0.2) per SD (22 nmol/L) decrease in 25(OH)D3. Conclusions: Both first pregnancy trimester during November-April and lower 25(OH)D3 were associated with earlier pubertal timing in girls and boys.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
25-hydroxyvitamin D
delayed effects
fetal programming
instrumental variable analysis
maternal exposure
pregnancy season
prenatal exposure
pubertal development
Seasonal effect
vitamin D

Added entries (persons, corporate bodies, meetings, titles ...)

Brix, NisAarhus University,Aarhus University Hospital (author)
Ernst, AndreasAarhus University,Aarhus University Hospital (author)
Lunddorf, Lea Lykke HarritsAarhus University (author)
Lindh, ChristianLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-cli (author)
Toft, GunnarAarhus University Hospital (author)
Henriksen, Tine BrinkAarhus University Hospital (author)
Arah, Onyebuchi A.Aarhus University,University of California, Los Angeles (author)
Ramlau-Hansen, Cecilia HøstUniversity of California, Los Angeles,Aarhus University (author)
University of California, Los AngelesAarhus University (creator_code:org_t)

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In:International Journal of Epidemiology52:5, s. 1328-13400300-5771

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