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Effects of a Highly...
Effects of a Highly Challenging Balance Training Program on Motor Function and Brain Structure in Parkinson's Disease
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- Albrecht, Franziska (författare)
- Karolinska Institute
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- Pereira, Joana B. (författare)
- Karolinska Institute,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Mijalkov, Mite (författare)
- Karolinska Institute
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- Freidle, Malin (författare)
- Karolinska Institute
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- Johansson, Hanna (författare)
- Karolinska Institute,Karolinska University Hospital
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- Ekman, Urban (författare)
- Karolinska Institute,Karolinska University Hospital
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- Westman, Eric (författare)
- Karolinska Institute
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- Franzén, Erika (författare)
- Karolinska Institute,Stockholms Sjukhem Foundation,Karolinska University Hospital
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(creator_code:org_t)
- IOS Press, 2021
- 2021
- Engelska 15 s.
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Ingår i: Journal of Parkinson's Disease. - : IOS Press. - 1877-7171 .- 1877-718X. ; 11:4, s. 2057-2071
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://content.iosp...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Parkinson's disease (PD) is characterized by motor deficits and brain alterations having a detrimental impact on balance, gait, and cognition. Intensive physical exercise can induce changes in the neural system, potentially counteracting neurodegeneration in PD and improving clinical symptoms. Objective: This randomized controlled trial investigated effects of a highly challenging, cognitively demanding, balance and gait training (HiBalance) program in participants with PD on brain structure. Methods: 95 participants were assigned to either the HiBalance or an active control speech training program. The group-based interventions were performed in 1-hour sessions, twice per week over a 10-week period. Participants underwent balance, gait, cognitive function, and structural magnetic resonance imaging assessments before and after the interventions. Voxel-based morphometry was analyzed in 34 HiBalance and 31 active controls. Additionally, structural covariance networks were assessed. Results: There was no significant time by group interaction between the HiBalance and control training in balance, gait, or brain volume. Within-HiBalance-group analyses showed higher left putamen volumes post-training. In repeated measures correlation a positive linear, non-significant relationship between gait speed and putamen volume was revealed. In the HiBalance group we found community structure changes and stronger thalamic-cerebellar connectivity in structural covariance networks. Neither brain volume changes nor topology changes were found for the active controls after the training. Conclusion: Thus, subtle structural brain changes occur after balance and gait training. Future studies need to determine whether training modifications or other assessment methods lead to stronger effects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- gait
- gray matter
- idiopathic Parkinson's disease
- magnetic resonance imaging
- physical exercise
- putamen
- Randomized controlled trial
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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