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- Albrecht, FranziskaKarolinska Institute (författare)
Effects of a Highly Challenging Balance Training Program on Motor Function and Brain Structure in Parkinson's Disease
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
- IOS Press,2021
- 15 s.
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:6a75fe0b-a603-4f03-8f33-bc0034ec2586
- https://lup.lub.lu.se/record/6a75fe0b-a603-4f03-8f33-bc0034ec2586URI
- https://doi.org/10.3233/jpd-212801DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Background: Parkinson's disease (PD) is characterized by motor deficits and brain alterations having a detrimental impact on balance, gait, and cognition. Intensive physical exercise can induce changes in the neural system, potentially counteracting neurodegeneration in PD and improving clinical symptoms. Objective: This randomized controlled trial investigated effects of a highly challenging, cognitively demanding, balance and gait training (HiBalance) program in participants with PD on brain structure. Methods: 95 participants were assigned to either the HiBalance or an active control speech training program. The group-based interventions were performed in 1-hour sessions, twice per week over a 10-week period. Participants underwent balance, gait, cognitive function, and structural magnetic resonance imaging assessments before and after the interventions. Voxel-based morphometry was analyzed in 34 HiBalance and 31 active controls. Additionally, structural covariance networks were assessed. Results: There was no significant time by group interaction between the HiBalance and control training in balance, gait, or brain volume. Within-HiBalance-group analyses showed higher left putamen volumes post-training. In repeated measures correlation a positive linear, non-significant relationship between gait speed and putamen volume was revealed. In the HiBalance group we found community structure changes and stronger thalamic-cerebellar connectivity in structural covariance networks. Neither brain volume changes nor topology changes were found for the active controls after the training. Conclusion: Thus, subtle structural brain changes occur after balance and gait training. Future studies need to determine whether training modifications or other assessment methods lead to stronger effects.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- gait
- gray matter
- idiopathic Parkinson's disease
- magnetic resonance imaging
- physical exercise
- putamen
- Randomized controlled trial
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Pereira, Joana B.Karolinska Institute,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)jo7228pe (författare)
- Mijalkov, MiteKarolinska Institute (författare)
- Freidle, MalinKarolinska Institute (författare)
- Johansson, HannaKarolinska Institute,Karolinska University Hospital (författare)
- Ekman, UrbanKarolinska Institute,Karolinska University Hospital (författare)
- Westman, EricKarolinska Institute (författare)
- Franzén, ErikaKarolinska Institute,Stockholms Sjukhem Foundation,Karolinska University Hospital (författare)
- Karolinska InstituteKlinisk minnesforskning (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of Parkinson's Disease: IOS Press11:4, s. 2057-20711877-71711877-718X
Internetlänk
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- Journal of Parkinson's Disease (Sök värdpublikationen i LIBRIS)
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