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  • Grasso, SilviaUniversity of Turin (author)

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-03-16
  • Springer Science and Business Media LLC,2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:6ae3c336-9647-487d-ad99-37637f13c699
  • https://lup.lub.lu.se/record/6ae3c336-9647-487d-ad99-37637f13c699URI
  • https://doi.org/10.1038/ncomms14797DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-positive status associates with a significantly lower probability of developing a distant event, and a clear difference in survival. p140Cap dampens ERBB2-positive tumour cell progression, impairing tumour onset and growth in the NeuT mouse model, and counteracting epithelial mesenchymal transition, resulting in decreased metastasis formation. One major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. Our findings point to a specific role of p140Cap in curbing the aggressiveness of ERBB2-amplified breast cancers and suggest that, due to its ability to impinge on specific molecular pathways, p140Cap may represent a predictive biomarker of response to targeted anti-ERBB2 therapies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Chapelle, JenniferUniversity of Turin (author)
  • Salemme, VincenzoUniversity of Turin (author)
  • Aramu, SimonaUniversity of Turin (author)
  • Russo, IsabellaUniversity of Turin (author)
  • Vitale, NicolettaUniversity of Turin (author)
  • Verdun di Cantogno, LudovicaUniversity of Turin (author)
  • Dallaglio, KatiusciaArcispedale Santa Maria Nuova (author)
  • Castellano, IsabellaUniversity of Turin (author)
  • Amici, AugustoUniversity of Camerino (author)
  • Centonze, GiorgiaUniversity of Turin (author)
  • Sharma, NanaochaUniversity of Turin (author)
  • Lunardi, SerenaUniversity of Turin (author)
  • Cabodi, SaraUniversity of Turin (author)
  • Cavallo, FedericaUniversity of Turin (author)
  • Lamolinara, AlessiaUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Stramucci, LorenzoUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Moiso, EnricoUniversity of Turin (author)
  • Provero, PaoloUniversity of Turin (author)
  • Albini, AdrianaIRCCS Multimedica (author)
  • Sapino, AnnaUniversity of Turin (author)
  • Staaf, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-jst (author)
  • Di Fiore, Pier PaoloUniversity of Milan (author)
  • Bertalot, GiovanniEuropean Institute of Oncology (author)
  • Pece, SalvatoreUniversity of Milan (author)
  • Tosoni, DanielaEuropean Institute of Oncology (author)
  • Confalonieri, StefanoIFOM - The FIRC Institute of Molecular Oncology (author)
  • Iezzi, ManuelaUniversity G.d'Annunzio of Chieti-Pescara (author)
  • Di Stefano, PaolaUniversity of Turin (author)
  • Turco, EmiliaUniversity of Turin (author)
  • Defilippi, PaolaUniversity of Turin (author)
  • University of TurinArcispedale Santa Maria Nuova (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC82041-1723

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