Gene expression profiling in MDS and AML: potential and future avenues.

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Theilgaard-Moench, KimLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine (author)

Gene expression profiling in MDS and AML: potential and future avenues.

Article/chapterEnglish2011

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2011-03-29
Springer Science and Business Media LLC,2011

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LIBRIS-ID:oai:lup.lub.lu.se:6b23654c-9ccf-4cfb-b503-355c45c5115b
https://lup.lub.lu.se/record/1883358URI
https://doi.org/10.1038/leu.2011.48DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

Notes

Today, the classification systems for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) already incorporate cytogenetic and molecular genetic aberrations in an attempt to better reflect disease biology. However, in many MDS/AML patients no genetic aberrations have been identified yet, and even within some cytogenetically well-defined subclasses there is considerable clinical heterogeneity. Recent advances in genomics technologies such as gene expression profiling (GEP) provide powerful tools to further characterize myeloid malignancies at the molecular level, with the goal to refine the MDS/AML classification system, incorporating as yet unknown molecular genetic and epigenetic pathomechanisms, which are likely reflected by aberrant gene expression patterns. In this study, we provide a comprehensive review on how GEP has contributed to a refined molecular taxonomy of MDS and AML with regard to diagnosis, prediction of clinical outcome, discovery of novel subclasses and identification of novel therapeutic targets and novel drugs. As many challenges remain ahead, we discuss the pitfalls of this technology and its potential including future integrative studies with other genomics technologies, which will continue to improve our understanding of malignant transformation in myeloid malignancies and thereby contribute to individualized risk-adapted treatment strategies for MDS and AML patients.Leukemia advance online publication, 29 March 2011; doi:10.1038/leu.2011.48.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
gene expression profiling
acute myeloid leukemia
myelodysplastic syndrome
microarray
connectivity MAP
drug discovery

Added entries (persons, corporate bodies, meetings, titles ...)

Boultwood, J (author)
Ferrari, S (author)
Giannopoulos, K (author)
Hernandez-Rivas, J M (author)
Kohlmann, A (author)
Morgan, M (author)
Porse, B (author)
Tagliafico, E (author)
Zwaan, C M (author)
Wainscoat, J (author)
Van den Heuvel-Eibrink, M M (author)
Mills, K (author)
Bullinger, L (author)
Stamcellscentrum (SCC)Avdelningen för stamcellsforskning (creator_code:org_t)

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In:Leukemia: Springer Science and Business Media LLC25:6, s. 909-9201476-55510887-6924

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By the author/editor: Theilgaard-Moenc ...; Boultwood, J; Ferrari, S; Giannopoulos, K; Hernandez-Rivas, ...; Kohlmann, A; show more...; Morgan, M; Porse, B; Tagliafico, E; Zwaan, C M; Wainscoat, J; Van den Heuvel-E ...; Mills, K; Bullinger, L; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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By the university: Lund University

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