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Effect of condition...
Effect of conditioned stimulus parameters on timing of conditioned purkinje cell responses
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- Svensson, Pär (författare)
- Lund University
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- Jirenhed, Dan-Anders (författare)
- Lund University,Lunds universitet,Associativ inlärning,Forskargrupper vid Lunds universitet,Associative Learning,Lund University Research Groups
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- Bengtsson, Fredrik (författare)
- Lund University,Lunds universitet,Hjärnans sensorimotoriska funktioner,Forskargrupper vid Lunds universitet,Neural Basis of Sensorimotor Control,Lund University Research Groups
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- Hesslow, Germund (författare)
- Lund University,Lunds universitet,Associativ inlärning,Forskargrupper vid Lunds universitet,Associative Learning,Lund University Research Groups
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(creator_code:org_t)
- American Physiological Society, 2010
- 2010
- Engelska 8 s.
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Ingår i: Journal of Neurophysiology. - : American Physiological Society. - 0022-3077 .- 1522-1598. ; 103:3, s. 1329-1336
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Pavlovian eyeblink conditioning is a useful experimental model for studying adaptive timing, an important aspect of skilled movements. The conditioned response (CR) is precisely timed to occur just before the onset of the expected unconditioned stimulus (US). The timing can be changed immediately, however, by varying parameters of the conditioned stimulus (CS). It has previously been shown that increasing the intensity of a peripheral CS or the frequency of a CS consisting of a train of stimuli to the mossy fibers shortens the latency of the CR. The adaptive timing of behavioral CRs probably reflects the timing of an underlying learned inhibitory response in cerebellar Purkinje cells. It is not known how the latency of this Purkinje cell CR is controlled. We have recorded form Purkinje cells in conditioned decerebrate ferrets while increasing the intensity of a peripheral CS or the frequency of a mossy fiber CS. We observe changes in the timing of the Purkinje cell CR that match the behavioral effects. The results are consistent with the effect of CS parameters on behavioral CR latency being caused by corresponding changes in Purkinje cell CRs. They suggest that synaptic temporal summation may be one of several mechanisms underlying adaptive timing of movements.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Animals
- Conditioning, Classical/physiology
- Decerebrate State/physiopathology
- Electric Stimulation
- Electromyography
- Electrophysiology
- Ferrets/physiology
- Forelimb/innervation
- Male
- Movement/physiology
- Nerve Fibers/physiology
- Purkinje Cells/physiology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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