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Dietary flavonoid i...
Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
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- Zamora-Ros, Raul (författare)
- International Agency for Research on Cancer, World Health Organization,Bellvitge Biomedical Research Institute
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- Barupal, Dinesh Kumar (författare)
- University of California, Davis,International Agency for Research on Cancer, World Health Organization
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- Rothwell, Joseph A. (författare)
- International Agency for Research on Cancer, World Health Organization,Institut Gustave Roussy,University of Paris-Saclay
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer, World Health Organization,Imperial College London
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- Fedirko, Veronika (författare)
- Emory University
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- Romieu, Isabelle (författare)
- International Agency for Research on Cancer, World Health Organization
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- Aleksandrova, Krasimira (författare)
- German Institute of Human Nutrition
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- Overvad, Kim (författare)
- Aarhus University
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- Kyrø, Cecilie (författare)
- Danish Cancer Society
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Affret, Aurélie (författare)
- Institut Gustave Roussy,University of Paris-Saclay
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- His, Mathilde (författare)
- Institut Gustave Roussy,University of Paris-Saclay
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- Boutron-Ruault, Marie-Christine (författare)
- Institut Gustave Roussy,University of Paris-Saclay
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- Katzke, Verena (författare)
- German Cancer Research Centre
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Naska, Androniki (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Kritikou, Maria (författare)
- Hellenic Health Foundation, Athens
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- Saieva, Calogero (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Agnoli, Claudia (författare)
- Istituto Nazionale dei Tumori
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- Santucci de Magistris, Maria (författare)
- University of Naples Federico II
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Fasanelli, Francesca (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,Karolinska Institute,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø
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- Merino, Susana (författare)
- Public Health Directorate
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- Jakszyn, Paula (författare)
- Bellvitge Biomedical Research Institute
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- Sánchez, Maria-José (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Dorronsoro, Miren (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Navarro, Carmen (författare)
- CIBER Epidemiology and Public Health (CIBERESP),University of Murcia,Murcia Regional Health Council
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Sonestedt, Emily (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Ericson, Ulrika (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Nilsson, Lena Maria (författare)
- Umeå universitet,Umeå University,Näringsforskning,Arktiskt centrum vid Umeå universitet (Arcum)
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- Bodén, Stina (författare)
- Umeå universitet,Umeå University,Onkologi
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- Bueno-De-Mesquita, Bas H. (författare)
- Imperial College London,University of Malaya,National Institute for Public Health and the Environment (RIVM)
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- Peeters, Petra H. (författare)
- Imperial College London,University Medical Center Utrecht
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- Perez-Cornago, Aurora (författare)
- University of Oxford
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- Wareham, Nicholas J (författare)
- University of Cambridge
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- Khaw, Kay-Thee (författare)
- University of Cambridge
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer, World Health Organization
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- Cross, Amanda J (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2017-01-19
- 2017
- Engelska 9 s.
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 140:8, s. 1836-1844
- Relaterad länk:
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93–1.18; p-trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- colorectal cancer
- diet
- EPIC
- flavonoids
- prospective cohort
- flavonoids
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Zamora-Ros, Raul
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Barupal, Dinesh ...
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Rothwell, Joseph ...
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Jenab, Mazda
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Fedirko, Veronik ...
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Romieu, Isabelle
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visa fler...
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Aleksandrova, Kr ...
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Overvad, Kim
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Kyrø, Cecilie
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Tjønneland, Anne
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Affret, Aurélie
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His, Mathilde
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Boutron-Ruault, ...
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Katzke, Verena
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Kühn, Tilman
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Boeing, Heiner
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Trichopoulou, An ...
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Naska, Androniki
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Kritikou, Maria
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Saieva, Calogero
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Agnoli, Claudia
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Santucci de Magi ...
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Tumino, Rosario
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Fasanelli, Franc ...
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Weiderpass, Elis ...
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Skeie, Guri
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Merino, Susana
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Jakszyn, Paula
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Sánchez, Maria-J ...
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Dorronsoro, Mire ...
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Navarro, Carmen
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Ardanaz, Eva
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Sonestedt, Emily
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Ericson, Ulrika
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Nilsson, Lena Ma ...
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Bodén, Stina
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Bueno-De-Mesquit ...
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Peeters, Petra H ...
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Perez-Cornago, A ...
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Wareham, Nichola ...
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Khaw, Kay-Thee
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Freisling, Heinz
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Cross, Amanda J
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Riboli, Elio
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Scalbert, August ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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International Jo ...
- Av lärosätet
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Lunds universitet
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Umeå universitet
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Karolinska Institutet