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Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention : The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention
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- McCaffery, Jeanne M. (author)
- University of Connecticut
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- Jablonski, Kathleen A. (author)
- George Washington University
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- Pan, Qing (author)
- George Washington University
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- Astrup, Arne (author)
- Novo Nordisk Foundation
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- Revsbech Christiansen, Malene (author)
- University of Copenhagen
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- Corella, Dolores (author)
- University of Valencia
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- Corso, Lauren M.L. (author)
- University of Connecticut
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- Florez, Jose C. (author)
- Broad Institute,Massachusetts General Hospital,Harvard Medical School
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
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- Gardner, Christopher (author)
- Stanford University School of Medicine
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- Hansen, Torben (author)
- University of Copenhagen
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- Kilpeläinen, Tuomas O. (author)
- University of Copenhagen
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- Knowler, William C. (author)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Lindström, Jaana (author)
- Finnish National Institute for Health and Welfare
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- Saris, Wim H.M. (author)
- Maastricht University
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- Sørensen, Thorkild I.A. (author)
- University of Copenhagen
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- Tuomilehto, Jaakko (author)
- University of Helsinki,Finnish National Institute for Health and Welfare,King Abdulaziz University
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- Uusitupa, Matti (author)
- University of Eastern Finland
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- Wing, Rena R. (author)
- Brown University
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- Agurs-Collins, Tanya (author)
- National Cancer Institute, USA
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(creator_code:org_t)
- 2022-01-18
- 2022
- English 8 s.
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In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 71:4, s. 669-676
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http://dx.doi.org/10...
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Abstract
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- Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI), but it remains unclear whether these SNPs relate to change in WCadjBMI or WHRadjBMI with lifestyle intervention for weight loss. We hypothesized that polygenic scores (PS) comprised of 59 SNPs previously associated with central adiposity would predict less of a reduction in WCadjBMI or WHRadjBMI at 8-10 weeks in two lifestyle intervention trials, NUGENOB and DiOGenes, and at 1 year in five lifestyle intervention trials, Look AHEAD, Diabetes Prevention Program, Diabetes Prevention Study, DIETFITS, and PREDIMED-Plus. One-SD higher PS related to a smaller 1-year change in WCadjBMI in the lifestyle intervention arms at year 1 and thus predicted poorer response (β = 0.007; SE = 0.003; P = 0.03) among White participants overall and in White men (β = 0.01; SE = 0.004; P = 0.01). At average weight loss, this amounted to 0.20-0.28 cm per SD. No significant findings emerged in White women or African American men for the 8-10-week outcomes or for WHRadjBMI. Findings were heterogeneous in African American women. These results indicate that polygenic risk estimated from these 59 SNPs relates to change in WCadjBMI with lifestyle intervention, but the effects are small and not of sufficient magnitude to be clinically significant.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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McCaffery, Jeann ...
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Jablonski, Kathl ...
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Pan, Qing
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Astrup, Arne
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Revsbech Christi ...
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Corella, Dolores
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show more...
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Corso, Lauren M. ...
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Florez, Jose C.
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Franks, Paul W.
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Gardner, Christo ...
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Hansen, Torben
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Kilpeläinen, Tuo ...
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Knowler, William ...
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Lindström, Jaana
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Saris, Wim H.M.
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Sørensen, Thorki ...
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Tuomilehto, Jaak ...
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Uusitupa, Matti
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Wing, Rena R.
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Agurs-Collins, T ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes
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Lund University