Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention : The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI), but it remains unclear whether these SNPs relate to change in WCadjBMI or WHRadjBMI with lifestyle intervention for weight loss. We hypothesized that polygenic scores (PS) comprised of 59 SNPs previously associated with central adiposity would predict less of a reduction in WCadjBMI or WHRadjBMI at 8-10 weeks in two lifestyle intervention trials, NUGENOB and DiOGenes, and at 1 year in five lifestyle intervention trials, Look AHEAD, Diabetes Prevention Program, Diabetes Prevention Study, DIETFITS, and PREDIMED-Plus. One-SD higher PS related to a smaller 1-year change in WCadjBMI in the lifestyle intervention arms at year 1 and thus predicted poorer response (β = 0.007; SE = 0.003; P = 0.03) among White participants overall and in White men (β = 0.01; SE = 0.004; P = 0.01). At average weight loss, this amounted to 0.20-0.28 cm per SD. No significant findings emerged in White women or African American men for the 8-10-week outcomes or for WHRadjBMI. Findings were heterogeneous in African American women. These results indicate that polygenic risk estimated from these 59 SNPs relates to change in WCadjBMI with lifestyle intervention, but the effects are small and not of sufficient magnitude to be clinically significant.

Jablonski, Kathleen A.George Washington University (author)
Pan, QingGeorge Washington University (author)
Astrup, ArneNovo Nordisk Foundation (author)
Revsbech Christiansen, MaleneUniversity of Copenhagen (author)
Corella, DoloresUniversity of Valencia (author)
Corso, Lauren M.L.University of Connecticut (author)
Florez, Jose C.Massachusetts General Hospital,Broad Institute,Harvard Medical School (author)
Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University(Swepub:lu)med-plf (author)
Gardner, ChristopherStanford University School of Medicine (author)
Hansen, TorbenUniversity of Copenhagen (author)
Kilpeläinen, Tuomas O.University of Copenhagen (author)
Knowler, William C.National Institute of Diabetes and Digestive and Kidney Diseases (author)
Lindström, JaanaFinnish National Institute for Health and Welfare (author)
Saris, Wim H.M.Maastricht University (author)
Sørensen, Thorkild I.A.University of Copenhagen (author)
Tuomilehto, JaakkoUniversity of Helsinki,Finnish National Institute for Health and Welfare,King Abdulaziz University (author)
Uusitupa, MattiUniversity of Eastern Finland (author)
Wing, Rena R.Brown University (author)
Agurs-Collins, TanyaNational Cancer Institute, USA (author)
University of ConnecticutGeorge Washington University (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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