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Outcome in dediffer...
Outcome in dedifferentiated chondrosarcoma for patients treated with multimodal therapy : Results from the EUROpean Bone Over 40 Sarcoma Study
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- Hompland, Ivar (author)
- Oslo university hospital
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- Ferrari, Stefano (author)
- Rizzoli Orthopedic Institute
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- Bielack, Stefan (author)
- Klinikum Stuttgart Olgahospital
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- Palmerini, Emanuela (author)
- Rizzoli Orthopedic Institute
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- Hall, Kirsten S. (author)
- Oslo university hospital
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- Picci, Pierro (author)
- Italian Sarcoma Group
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- Hecker-Nolting, Stefanie (author)
- Klinikum Stuttgart Olgahospital
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- Donati, Davide M. (author)
- Rizzoli Orthopedic Institute
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- Blattmann, Claudia (author)
- Klinikum Stuttgart Olgahospital
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- Bjerkehagen, Bodil (author)
- Oslo university hospital
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- Staals, Eric (author)
- Rizzoli Orthopedic Institute
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- Kager, Leo (author)
- Medical University of Vienna
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- Gambarotti, Marco (author)
- Rizzoli Orthopedic Institute
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- Kühne, Thomas (author)
- University Children's Hospital, Basel
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- Eriksson, Mikael (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Ferraresi, Virginia (author)
- National Cancer Institute Regina Elena
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- Kevric, Matthias (author)
- Klinikum Stuttgart Olgahospital
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- Biagini, Roberto (author)
- National Cancer Institute Regina Elena
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- Baumhoer, Daniel (author)
- University Hospital Basel
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- Brosjø, Otte (author)
- Karolinska University Hospital
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- Comandone, Alessandro (author)
- Ospedale Humanitas Gradenigo
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- Schwarz, Rudolf (author)
- University Medical Center Hamburg-Eppendorf
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- Bertulli, Rossella (author)
- Istituto Nazionale dei Tumori
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- Kessler, Torsten (author)
- University Hospital Münster
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- Hansson, Lina (author)
- Sahlgrenska University Hospital
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- Apice, Gaetano (author)
- Istituto Nazionale dei Tumori
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- Heydrich, Björn N. (author)
- University Medical Center Schleswig-Holstein
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- Setola, Elisabetta (author)
- Rizzoli Orthopedic Institute
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- Flörcken, Anne (author)
- Berlin Institute of Health (BIH)
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- Ruggieri, Pietro (author)
- University of Padova
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- Krasniqi, Fatime (author)
- University Hospital Basel
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- Hofmann-Wackersreuther, Gerda (author)
- Klinikum Nürnberg
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- Casali, Paolo (author)
- Istituto Nazionale dei Tumori
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- Reichardt, Peter (author)
- HELIOS Klinikum Berlin-Buch
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- Smeland, Sigbjørn (author)
- Oslo university hospital
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English 9 s.
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In: European Journal of Cancer. - : Elsevier BV. - 0959-8049. ; 151, s. 150-158
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http://www.ejcancer....
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Abstract
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- Introduction: The role of chemotherapy for patients with dedifferentiated chondrosarcoma (DDCS) is still under discussion. Here, we present the outcome in patients with DDCS treated with intensive chemotherapy from the EUROpean Bone Over 40 Sarcoma Study. Materials and methods: The chemotherapy regimen included doxorubicin, ifosfamide and cisplatin. Postoperative methotrexate was added in case of poor histological response. Toxicity was graded based on the National Cancer Institute expanded common toxicity criteria, version 2.0, and survival was analysed using Kaplan-Meier curves, log-rank tests and univariate Cox regression models. Results: Fifty-seven patients with DDCS (localised, 34 [60%]; metastatic, 23 [40%]) aged 42–65 years were included. Surgical complete remission (SCR) was achieved in 36 (63%) patients. The median overall survival (OS) was 24 months (95% confidence interval, 22–25), and the 5-year OS was 39%. Patients with extremity localisation had a 5-year OS of 49% compared with 29% in patients with a central tumour (P = 0.08). Patients with localised disease had a 5-year OS of 46%, whereas patients with metastatic disease had a 5-year OS of 29% (P = 0.12). Patients in SCR had a 5-year OS of 49%, whereas patients not in SCR had a 5-year OS of 23% (P = 0.004). Chemotherapy toxicity was considerable but manageable. There was no treatment-related death, and 39 (70%) patients received ≥6 cycles of the planned nine chemotherapy cycles. Conclusions: Adding intensive chemotherapy to surgery for treatment of DDCS is feasible and shows favourable survival data compared with previous reports. With the limitations of data from a non-controlled trial, we conclude that chemotherapy could be considered in the management of patients aged >40 years.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Bone sarcoma
- Chemotherapy
- Complete surgical remission
- Dedifferentiated chondrosarcoma
- EURO-B.O.S.S.
- Sarcoma
- Survival
- Systemic treatment
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Hompland, Ivar
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Ferrari, Stefano
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Bielack, Stefan
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Palmerini, Emanu ...
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Hall, Kirsten S.
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Picci, Pierro
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Hecker-Nolting, ...
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Donati, Davide M ...
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Blattmann, Claud ...
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Bjerkehagen, Bod ...
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Staals, Eric
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Kager, Leo
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Gambarotti, Marc ...
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Kühne, Thomas
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Eriksson, Mikael
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Ferraresi, Virgi ...
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Kevric, Matthias
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Biagini, Roberto
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Baumhoer, Daniel
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Brosjø, Otte
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Comandone, Aless ...
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Schwarz, Rudolf
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Bertulli, Rossel ...
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Kessler, Torsten
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Hansson, Lina
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Apice, Gaetano
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Heydrich, Björn ...
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Setola, Elisabet ...
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Flörcken, Anne
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Ruggieri, Pietro
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Krasniqi, Fatime
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Hofmann-Wackersr ...
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Casali, Paolo
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Reichardt, Peter
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Smeland, Sigbjør ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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European Journal ...
- By the university
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Lund University