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Identification of p...
Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
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Brekke, Helge R. (author)
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Kolberg, Matthias (author)
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Skotheim, Rolf I. (author)
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Hall, Kirsten S. (author)
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Bjerkehagen, Bodil (author)
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Risberg, Bjorn (author)
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- Domanski, Henryk (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Mandahl, Nils (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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Liestol, Knut (author)
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Smeland, Sigbjorn (author)
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Danielsen, Havard E. (author)
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- Mertens, Fredrik (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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Lothe, Ragnhild A. (author)
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(creator_code:org_t)
- 2009-10
- 2009
- English.
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In: Neuro-Oncology. - : Oxford University Press (OUP). - 1523-5866 .- 1522-8517. ; 11:5, s. 514-528
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http://dx.doi.org/10...
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https://europepmc.or...
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Abstract
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- The purpose of this study was to identify new prognostic biomarkers with clinical impact in malignant peripheral nerve sheath tumor (MPNST), a highly aggressive malignancy for which no consensus therapy exists besides surgery. We have used tissue microarrays (TMAs) to assess in situ expression of 14 cell-cycle-regulating proteins in 64 well-characterized MPNST patients: 36 sporadic and 28 with neurofibromatosis type 1 (NF1). We developed a new software application for evaluation and logistics of the TMA images and performed a literature survey of cell cycle proteins in MPNST. For NF1-associated patients, there was a clear association between nuclear expression of p53 and poor survival (p = 0.004). Among the other proteins analyzed, we also found significant associations between survival and clinical variables, but none were as strong as that for p53. For the total series of MPNSTs, p53 was shown to be an independent predictor of survival, and patients without remission, with tumor size larger than 8 cm, and with positive p53 expression had a 60 times greater risk of dying within the first 5 years compared with the remaining patients (p = 0.000002). This is the most comprehensive study of in situ protein expression in MPNST so far, and expressed p53 was found to be a strong surrogate marker for outcome. Patients in complete remission with a primary p53-positive MPNST diagnosis may be considered in a high-risk subgroup and candidates for adjuvant treatment. Neuro-Oncology 11, 514-528, 2009 (Posted to Neuro-Oncology [serial online], Doc. D08-00271, January 30, 2009.)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- neurofibroma
- cyclin D1
- MPNST
- NF1
- p53
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Brekke, Helge R.
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Kolberg, Matthia ...
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Skotheim, Rolf I ...
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Hall, Kirsten S.
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Bjerkehagen, Bod ...
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Risberg, Bjorn
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show more...
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Domanski, Henryk
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Mandahl, Nils
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Liestol, Knut
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Smeland, Sigbjor ...
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Danielsen, Havar ...
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Mertens, Fredrik
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Lothe, Ragnhild ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Neuro-Oncology
- By the university
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Lund University