Is the lack of concurrence of bacterial vaginosis and vaginal candidosis explained by the presence of bacterial amines?

• OBJECTIVE AND STUDY DESIGN: We report for the first time an inhibitory effect on cell division and germ tube formation by Candida albicans and strains of other Candida species by putrescine and cadaverine. RESULTS: Both bacterial amines showed a dose-dependent inhibition of germ tube formation by C albicans, as well as budding (inhibition of cell division) of strains of other Candida species (ie, C glabrata, C krusei, and C tropicalis). CONCLUSIONS: We hypothesize that the presence of these and possibly other bacterial amines produced by anaerobes in the vaginal flora and seen in bacterial vaginosis, as in the healthy gut, may explain why candidosis is rarely seen in these instances.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

Candida albicans

Vaginitis

Bacteriosis

Candidiasis

Putrescine

Cadaverine

Inhibitor

Germination

Concomitant disease

Vaginal fluid

Pathogenesis

Human

Female

Infection

Mycosis

Fungi Imperfecti

Fungi

Thallophyta

Female genital diseases

Vaginal diseases

Amine

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)