Is the lack of concurrence of bacterial vaginosis and vaginal candidosis explained by the presence of bacterial amines?

OBJECTIVE AND STUDY DESIGN: We report for the first time an inhibitory effect on cell division and germ tube formation by Candida albicans and strains of other Candida species by putrescine and cadaverine. RESULTS: Both bacterial amines showed a dose-dependent inhibition of germ tube formation by C albicans, as well as budding (inhibition of cell division) of strains of other Candida species (ie, C glabrata, C krusei, and C tropicalis). CONCLUSIONS: We hypothesize that the presence of these and possibly other bacterial amines produced by anaerobes in the vaginal flora and seen in bacterial vaginosis, as in the healthy gut, may explain why candidosis is rarely seen in these instances.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
Candida albicans
Vaginitis
Bacteriosis
Candidiasis
Putrescine
Cadaverine
Inhibitor
Germination
Concomitant disease
Vaginal fluid
Pathogenesis
Human
Female
Infection
Mycosis
Fungi Imperfecti
Fungi
Thallophyta
Female genital diseases
Vaginal diseases
Amine

Mårdh, Per-AndersLund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)gyn-pam (författare)
Pina-Vaz, C (författare)
Martinez-de-Oliveira, J (författare)
da Fonseca, A F (författare)
Obstetrik och gynekologi, LundSektion V (creator_code:org_t)

Av författaren/redakt...: Rodrigues, A G; Mårdh, Per-Ander ...; Pina-Vaz, C; Martinez-de-Oliv ...; da Fonseca, A F

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

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