Small intestinal CD103(+) dendritic cells display unique functional properties that are conserved between mice and humans

Jaensson Gyllenbäck, ElinLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups (author)

A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD103(+) DCs. CD103(+) SI-LP DCs appeared to derive from circulating DC precursors that continually seed the SI- LP. BrdU pulse-chase experiments suggested that most CD103(+) DCs do not derive from a CD103(-) SI- LP DC intermediate. The majority of CD103(+) MLN DCs appear to represent a tissue- derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8(+) and CD4(+) T cells. In contrast, most CD103(+) MLN DCs appear to derive from blood precursors, and these cells could proliferate within the MLN and present systemic soluble antigen. Critically, CD103(+) DCs with similar phenotype and functional properties were present in human MLN, and their selective ability to induce CCR9 was maintained by CD103(+) MLN DCs isolated from SB Crohn ' s patients. Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal infl ammatory responses.

Uronen-Hansson, HeliLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)med-hiu (author)
Pabst, Oliver (author)
Eksteen, Bertus (author)
Tian, Jiong (author)
Coombes, Janine L. (author)
Berg, Pia-Lena (author)
Davidsson, ThomasLund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups(Swepub:lu)urok-tda (author)
Powrie, Fiona (author)
Johansson Lindbom, BengtLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)immt-bjo (author)
Agace, WilliamLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)immu-wag (author)
ImmunologiForskargrupper vid Lunds universitet (creator_code:org_t)

In:Journal of Experimental Medicine: Rockefeller University Press205:9, s. 2139-21491540-95380022-1007

By the author/editor: Jaensson Gyllenb ...; Uronen-Hansson, ...; Pabst, Oliver; Eksteen, Bertus; Tian, Jiong; Coombes, Janine ...; show more...; Berg, Pia-Lena; Davidsson, Thoma ...; Powrie, Fiona; Johansson Lindbo ...; Agace, William; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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