Search: WFRF:(Meijer C. J. L. M.)
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Population-based ty...
Population-based type-specific prevalence of high-risk human papillomavirus infection in middle-aged Swedish Women.
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- Forslund, Ola (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Antonsson, Annika (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Edlund, Karin (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Virologi
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- van Den Brule, Adrian J C (author)
- Karolinska Institutet
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- Hansson, Bengt-Göran (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Meijer, Chris J L M (author)
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Ryd, Walter (author)
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Rylander, Eva (author)
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Strand, Anders (author)
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- Wadell, Göran (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Virologi
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- Dillner, Joakim (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Johansson, Bo (author)
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(creator_code:org_t)
- 2002-02-05
- 2002
- English.
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In: Journal of Medical Virology. - : Wiley. - 1096-9071 .- 0146-6615. ; 66:4, s. 535-541
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Abstract
Subject headings
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- Human papillomavirus (HPV) DNA testing can be used to identify women at risk of the development of cervical cancer. The cost-effectiveness of HPV screening is dependent on the type-specific HPV prevalence in the general population. The present study describes the prevalence and spectrum of high-risk HPV types found in a large real-life population-based HPV screening trial undertaken entirely within the cervical screening program offered to middle-aged Swedish women. Cervical brush samples from 6,123 women aged 32-38 years were analyzed using a general HPV primer (GP5(+)/6(+)) polymerase chain reaction-enzyme immunoassay (PCR-EIA) combined with reverse dot-blot hybridization for confirmation and HPV typing by a single assay. In this study, 6.8% (95% CI 6.2-7.5) (417/6,123) were confirmed as high-risk HPV positive. Infections with 13 different high-risk HPV types were detected, of which HPV 16 was the most prevalent type (2.1%; 128/6,123), followed by HPV 31 (1.1%; 67/6,123). Any one of the HPV types 18, 33, 35, 39, 45, 51, 52, 56, 58, 59, or 66 was detected in 3.6% (223/6,123) of the women. Infection with two, three, and five types simultaneously was identified in 32, 5, and 1 women, respectively. The combination of PCR-EIA as a screening test and reverse dot-blot hybridization as a confirmatory test, was found to be readily applicable to a real-life population-based cervical screening. The type-specific HPV prevalence found support in previous modeling studies suggesting that HPV screening may be a favorable cervical screening strategy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Human papillomavirus
- Women
- Mass Screening
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Forslund, Ola
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Antonsson, Annik ...
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Edlund, Karin
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van Den Brule, A ...
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Hansson, Bengt-G ...
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Meijer, Chris J ...
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show more...
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Ryd, Walter
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Rylander, Eva
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Strand, Anders
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Wadell, Göran
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Dillner, Joakim
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Johansson, Bo
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Journal of Medic ...
- By the university
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Lund University
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Umeå University
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Karolinska Institutet