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Cardiovascular Prot...
Cardiovascular Proteomics : A Post Hoc Analysis from a Phase II Randomized Clinical Trial Comparing GnRH Antagonist vs GnRH Agonist among Men with Advanced Prostate Cancer
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- Lifshitz, Karin (författare)
- Israel Defense Forces
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- Ber, Yaara (författare)
- Rabin Medical Center
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- Shenhar, Chen (författare)
- Rabin Medical Center
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- Nillson, Jan (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital
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- Peer, Avivit (författare)
- Technion - Israel Institute of Technology
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- Rosenbaum, Eli (författare)
- Rabin Medical Center
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- Baniel, Jack (författare)
- Rabin Medical Center,Tel-Aviv University
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- Kedar, Daniel (författare)
- Rabin Medical Center
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- Ben Zadok, Osnat Itzhaki (författare)
- Tel-Aviv University,Rabin Medical Center
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- Margel, David (författare)
- Rabin Medical Center
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(creator_code:org_t)
- 2021
- 2021
- Engelska 8 s.
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Ingår i: The Journal of urology. - 1527-3792. ; 206:4, s. 952-959
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE: Recent studies demonstrated reduced cardiovascular (CV) risk with gonadotropin-releasing hormone (GnRH) antagonist, yet the underlying mechanism remains undetermined. The objective of this study was to examine longitudinal changes over time in established CV related proteins among men treated with GnRH agonists vs GnRH antagonist. MATERIALS AND METHODS: We performed a proteomics analysis of serum samples collected during a phase II randomized study among 80 men with advanced prostate cancer and preexisting CV disease who were randomized to receive a GnRH agonist (39) or GnRH antagonist (41) for 1 year. Serum samples were collected at baseline and at 3, 6 and 12 months following treatment, and analyzed levels of 188 proteins using the CV panel II and III of the Olink Multiplex platform (Olink Proteomics AB, Uppsala, Sweden). We fitted a linear mixed effects model to assess evidence of a treatment effect across CV related protein values. This included terms for treatment arm, protein levels and time-by-treatment interaction. Results were corrected for multiple testing using the Benjamini-Hochberg method. RESULTS: The CV proteomics analysis included 283 samples from 78 subjects. We identified 5 proteins with distinct patterns over time depending on study arm: human chitotriosidase, macrophage receptor with collagenous structure, cathepsin D, superoxide dismutase 2 and hydroxyacid oxidase 1. All 5 are associated with plaque stability and demonstrated an increased level among subjects in the GnRH antagonist arm compared to agonist. CONCLUSIONS: We compared longitudinal changes in CV proteins among men using androgen deprivation therapy. Our results support a direct protective effect of GnRH antagonist on plaque stability rather than a hazardous consequence of GnRH agonists on plaque rupture. This is a hypothesis generating study, and requires further confirmation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- biomarkers
- cardiovascular physiological phenomena
- gonadotropin-releasing hormone
- prostatic neoplasms
- proteomics
Publikations- och innehållstyp
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Till lärosätets databas
- Av författaren/redakt...
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Lifshitz, Karin
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Ber, Yaara
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Shenhar, Chen
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Nillson, Jan
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Peer, Avivit
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Rosenbaum, Eli
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visa fler...
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Baniel, Jack
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Kedar, Daniel
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Ben Zadok, Osnat ...
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Margel, David
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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The Journal of u ...
- Av lärosätet
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Lunds universitet