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Accrual of Atherosc...
Accrual of Atherosclerotic Vascular Events in a Multicenter Inception Systemic Lupus Erythematosus Cohort
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- Urowitz, Murray B. (författare)
- University of Toronto
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- Gladman, Dafna D. (författare)
- University of Toronto
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- Farewell, Vernon (författare)
- University of Cambridge
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- Su, Jiandong (författare)
- University of Toronto
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- Romero-Diaz, Juanita (författare)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Bae, Sang Cheol (författare)
- Hanyang University
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- Fortin, Paul R. (författare)
- Laval University
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- Sanchez-Guerrero, Jorge (författare)
- University of Toronto
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- Clarke, Ann Elaine (författare)
- University of Calgary
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- Bernatsky, Sasha (författare)
- McGill University Health Center
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- Gordon, Caroline (författare)
- University of Birmingham
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- Hanly, John G. (författare)
- Dalhousie University
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- Wallace, Daniel J. (författare)
- University of California, Los Angeles
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- Isenberg, David A. (författare)
- Royal Free Hospital
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- Rahman, Anisur (författare)
- Royal Free Hospital
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- Merrill, Joan T. (författare)
- Oklahoma Medical Research Foundation
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- Ginzler, Ellen (författare)
- SUNY Downstate Health Sciences University
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- Alarcón, Graciela S. (författare)
- University of Alabama
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- Chatham, W. Winn (författare)
- University of Alabama
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- Petri, Michelle A. (författare)
- Johns Hopkins University School of Medicine
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- Bruce, Ian N. (författare)
- University of Manchester
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- Khamashta, Munther A. (författare)
- King's College London,St Thomas' Hospital
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- Aranow, Cynthia (författare)
- Feinstein Institute for Medical Research
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- Dooley, Mary Anne (författare)
- University of North Carolina
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- Manzi, Susan (författare)
- Allegheny Health Network
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- Ramsey-Goldman, Rosalind (författare)
- Northwestern University
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- Nived, Ola (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Steinsson, Kristján (författare)
- National University Hospital of Iceland
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- Zoma, Asad A. (författare)
- Hairmyres Hospital
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- Ruiz-Irastorza, Guillermo (författare)
- University of the Basque Country
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- Lim, S. Sam (författare)
- Emory University
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- Kalunian, Kenneth C. (författare)
- University of California, San Diego
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- Ỉnanç, Murat (författare)
- Istanbul University
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- van Vollenhoven, Ronald (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Ramos-Casals, Manuel (författare)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Kamen, Diane L. (författare)
- Medical University of South Carolina
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- Jacobsen, Soren (författare)
- Copenhagen University Hospital
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- Peschken, Christine A. (författare)
- University of Manitoba
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- Askanase, Anca (författare)
- Indian Institute of Technology
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- Stoll, Thomas (författare)
- Cantonal Hospital of Olten
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(creator_code:org_t)
- 2020-08-25
- 2020
- Engelska 7 s.
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Ingår i: Arthritis and Rheumatology. - : Wiley. - 2326-5191 .- 2326-5205. ; 72:10, s. 1734-1740
- Relaterad länk:
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http://dx.doi.org/10...
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http://pure-oai.bham...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: In previous studies, atherosclerotic vascular events (AVEs) were shown to occur in ~10% of patients with systemic lupus erythematosus (SLE). We undertook this study to investigate the annual occurrence and potential risk factors for AVEs in a multinational, multiethnic inception cohort of patients with SLE. Methods: A large 33-center cohort of SLE patients was followed up yearly between 1999 and 2017. AVEs were attributed to atherosclerosis based on SLE being inactive at the time of the AVE as well as typical atherosclerotic changes observed on imaging or pathology reports and/or evidence of atherosclerosis elsewhere. Analyses included descriptive statistics, rate of AVEs per 1,000 patient-years, and univariable and multivariable relative risk regression models. Results: Of the 1,848 patients enrolled in the cohort, 1,710 had ≥1 follow-up visit after enrollment, for a total of 13,666 patient-years. Of these 1,710 patients, 3.6% had ≥1 AVEs attributed to atherosclerosis, for an event rate of 4.6 per 1,000 patient-years. In multivariable analyses, lower AVE rates were associated with antimalarial treatment (hazard ratio [HR] 0.54 [95% confidence interval (95% CI) 0.32–0.91]), while higher AVE rates were associated with any prior vascular event (HR 4.00 [95% CI 1.55–10.30]) and a body mass index of >40 kg/m2 (HR 2.74 [95% CI 1.04–7.18]). A prior AVE increased the risk of subsequent AVEs (HR 5.42 [95% CI 3.17–9.27], P < 0.001). Conclusion: The prevalence of AVEs and the rate of AVE accrual demonstrated in the present study is much lower than that seen in previously published data. This may be related to better control of both the disease activity and classic risk factors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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Urowitz, Murray ...
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Gladman, Dafna D ...
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Farewell, Vernon
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Su, Jiandong
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Romero-Diaz, Jua ...
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Bae, Sang Cheol
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visa fler...
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Fortin, Paul R.
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Sanchez-Guerrero ...
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Clarke, Ann Elai ...
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Bernatsky, Sasha
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Gordon, Caroline
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Hanly, John G.
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Ginzler, Ellen
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Alarcón, Graciel ...
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Chatham, W. Winn
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Petri, Michelle ...
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Bruce, Ian N.
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Khamashta, Munth ...
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Aranow, Cynthia
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Dooley, Mary Ann ...
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Manzi, Susan
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Ramsey-Goldman, ...
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Nived, Ola
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Jönsen, Andreas
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Steinsson, Krist ...
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Zoma, Asad A.
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Kalunian, Kennet ...
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Ỉnanç, Murat
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van Vollenhoven, ...
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Ramos-Casals, Ma ...
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Kamen, Diane L.
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Jacobsen, Soren
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Peschken, Christ ...
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Askanase, Anca
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Stoll, Thomas
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