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Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device : Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA)
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- Ammirati, Enrico (author)
- Niguarda Hospital
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- Brambatti, Michela (author)
- Jonsson Comprehensive Cancer Center
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- Braun, Oscar (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Shah, Palak (author)
- Inova Heart and Vascular Institute
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- Cipriani, Manlio (author)
- Niguarda Hospital
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- Bui, Quan M. (author)
- Jonsson Comprehensive Cancer Center
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- Veenis, Jesse (author)
- Erasmus University Medical Center
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- Lee, Euyhyun (author)
- Altman Clinical and Translational Research Institute
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- Xu, Ronghui (author)
- Altman Clinical and Translational Research Institute,University of California, San Diego
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- Hong, Kimberly N. (author)
- Jonsson Comprehensive Cancer Center
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- Van de Heyning, Caroline M. (author)
- Antwerp University Hospital
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- Perna, Enrico (author)
- Niguarda Hospital
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- Timmermans, Philippe (author)
- University Hospitals Leuven
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- Cikes, Maja (author)
- University Hospital of Infectious Diseases
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- Brugts, Jasper J. (author)
- Erasmus University Medical Center
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- Veronese, Giacomo (author)
- University of Milano-Bicocca,Niguarda Hospital
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- Minto, Jonathan (author)
- Inova Heart and Vascular Institute
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- Smith, Saige (author)
- Jonsson Comprehensive Cancer Center
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- Gjesdal, Grunde (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Gernhofer, Yan K. (author)
- Jonsson Comprehensive Cancer Center
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- Partida, Cynthia (author)
- University of California, San Francisco
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- Potena, Luciano (author)
- St. Orsola-Malpighi University Hospital
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- Masetti, Marco (author)
- St. Orsola-Malpighi University Hospital
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- Boschi, Silvia (author)
- St. Orsola-Malpighi University Hospital
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- Loforte, Antonio (author)
- St. Orsola-Malpighi University Hospital
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- Jakus, Nina (author)
- University Hospital of Infectious Diseases
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- Milicic, Davor (author)
- University Hospital of Infectious Diseases
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- Nilsson, Johan (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- De Bock, Dina (author)
- Antwerp University Hospital
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- Sterken, Caroline (author)
- University Hospitals Leuven
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- Van den Bossche, Klaartje (author)
- University Hospitals Leuven
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- Rega, Filip (author)
- University Hospitals Leuven
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- Tran, Hao (author)
- Jonsson Comprehensive Cancer Center
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- Singh, Ramesh (author)
- Inova Heart and Vascular Institute
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- Montomoli, Jonathan (author)
- Marche Polytechnic University
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- Mondino, Michele (author)
- Niguarda Hospital
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- Greenberg, Barry (author)
- Jonsson Comprehensive Cancer Center
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- Russo, Claudio F. (author)
- Niguarda Hospital
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- Pretorius, Victor (author)
- Jonsson Comprehensive Cancer Center
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- Liviu, Klein (author)
- University of California, San Francisco
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- Frigerio, Maria (author)
- Niguarda Hospital
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- Adler, Eric D. (author)
- Jonsson Comprehensive Cancer Center
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273. ; 324
- Related links:
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http://dx.doi.org/10...
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https://lirias.kuleu...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Background: Geographic variations in management and outcomes of individuals supported by continuous-flow left ventricular assist devices (CF-LVAD) between the United States (US) and Europe (EU) is largely unknown. Methods: We created a retrospective, multinational registry of 524 patients who received a CF-LVAD (either HVAD or Heartmate II) between January 2008 and April 2017. Follow up spanned from date of CF-LVAD implant to post-HTx period with a median follow up of 44.8 months. Results: The cohort included 299 (57.1%) EU and 225 (42.9%) US patients. Although the US cohort was significantly older with a higher prevalence of comorbidities, survival was similar between the cohorts (US 63.1%, EU 68.4% at 5 years, unadjusted log-rank test p = 0.43).Multivariate analyses suggested that older age, higher body mass index, elevated creatinine, use of temporary mechanical circulatory support prior CF-LVAD, and implantation of HVAD were associated with increased mortality. Among CF-LVAD patients undergoing HTx, the median time on CF-LVAD support was shorter in the US, meanwhile US donors were younger. Finally, the pattern of adverse events (stroke, gastrointestinal bleedings, late right ventricular failure, and driveline infection) during support differed significantly between US and EU. Conclusions: Although waitlisted patients in the US on CF-LVAD have higher risk comorbid conditions, the overall outcome is similar in US and EU. Geographic variations with regards to donor characteristics, duration of CF-LVAD support prior to transplant, and adverse events on support can explain the disparity in the utilization of mechanical bridge to transplant strategy between US and EU.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Bridge to transplantation
- Continuous flow left ventricular assist device
- Donor heart
- Heart transplant list
- Heart transplantation
- Outcome
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ammirati, Enrico
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Brambatti, Miche ...
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Braun, Oscar
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Shah, Palak
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Cipriani, Manlio
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Bui, Quan M.
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show more...
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Veenis, Jesse
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Lee, Euyhyun
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Xu, Ronghui
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Hong, Kimberly N ...
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Van de Heyning, ...
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Perna, Enrico
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Timmermans, Phil ...
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Cikes, Maja
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Brugts, Jasper J ...
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Veronese, Giacom ...
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Minto, Jonathan
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Smith, Saige
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Gjesdal, Grunde
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Gernhofer, Yan K ...
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Partida, Cynthia
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Potena, Luciano
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Masetti, Marco
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Boschi, Silvia
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Loforte, Antonio
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Jakus, Nina
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Milicic, Davor
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Nilsson, Johan
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De Bock, Dina
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Sterken, Carolin ...
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Van den Bossche, ...
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Rega, Filip
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Tran, Hao
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Singh, Ramesh
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Montomoli, Jonat ...
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Mondino, Michele
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Greenberg, Barry
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Russo, Claudio F ...
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Pretorius, Victo ...
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Liviu, Klein
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Frigerio, Maria
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Adler, Eric D.
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- MEDICAL AND HEALTH SCIENCES
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Lund University