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New hallmarks of ag...
New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary
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- Schmauck-Medina, Tomas (author)
- Akershus University Hospital
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- Molière, Adrian (author)
- Akershus University Hospital
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- Lautrup, Sofie (author)
- Akershus University Hospital
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- Zhang, Jianying (author)
- Akershus University Hospital
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- Chlopicki, Stefan (author)
- Jagiellonian University
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- Madsen, Helena Borland (author)
- University of Copenhagen
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- Cao, Shuqin (author)
- Akershus University Hospital
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- Soendenbroe, Casper (author)
- Bispebjerg Hospital
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- Mansell, Els (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,UCL Cancer Institute,University College London
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- Vestergaard, Mark Bitsch (author)
- Copenhagen University Hospital
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- Li, Zhiquan (author)
- University of Copenhagen
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- Shiloh, Yosef (author)
- Tel-Aviv University
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- Opresko, Patricia L. (author)
- University of Pittsburgh
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- Egly, Jean Marc (author)
- University of Strasbourg
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- Kirkwood, Thomas (author)
- University of Newcastle upon Tyne,University of Copenhagen
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- Verdin, Eric (author)
- Buck Institute for Research on Aging
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- Bohr, Vilhelm A. (author)
- National Institute on Aging, United States,University of Copenhagen
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- Cox, Lynne S. (author)
- University of Oxford
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- Stevnsner, Tinna (author)
- Aarhus University
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- Rasmussen, Lene Juel (author)
- University of Copenhagen
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- Fang, Evandro F. (author)
- Akershus University Hospital
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(creator_code:org_t)
- 2022-08-29
- 2022
- English 11 s.
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In: Aging. - : Impact Journals, LLC. - 1945-4589. ; 14:16, s. 6829-6839
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Keyword
- Autophagy
- Hallmarks of ageing
- Healthspan
- Longevity
- Neurodegeneration
Publication and Content Type
- art (subject category)
- ref (subject category)
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Aging
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Schmauck-Medina, ...
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Molière, Adrian
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Lautrup, Sofie
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Zhang, Jianying
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Chlopicki, Stefa ...
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Madsen, Helena B ...
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show more...
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Cao, Shuqin
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Soendenbroe, Cas ...
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Mansell, Els
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Vestergaard, Mar ...
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Li, Zhiquan
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Shiloh, Yosef
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Opresko, Patrici ...
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Egly, Jean Marc
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Kirkwood, Thomas
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Verdin, Eric
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Bohr, Vilhelm A.
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Cox, Lynne S.
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Stevnsner, Tinna
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Rasmussen, Lene ...
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Fang, Evandro F.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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Aging
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Lund University