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  • Mansour Aly, DinaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups (author)

Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-11-04
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:6ed784f1-24f1-4a0d-9b59-ba9be7d1a5e1
  • https://lup.lub.lu.se/record/6ed784f1-24f1-4a0d-9b59-ba9be7d1a5e1URI
  • https://doi.org/10.1038/s41588-021-00948-2DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148379480URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Type 2 diabetes has been reproducibly clustered into five subtypes with different disease progression and risk of complications; however, etiological differences are unknown. We used genome-wide association and genetic risk score (GRS) analysis to compare the underlying genetic drivers. Individuals from the Swedish ANDIS (All New Diabetics In Scania) study were compared to individuals without diabetes; the Finnish DIREVA (Diabetes register in Vasa) and Botnia studies were used for replication. We show that subtypes differ with regard to family history of diabetes and association with GRS for diabetes-related traits. The severe insulin-resistant subtype was uniquely associated with GRS for fasting insulin but not with variants in the TCF7L2 locus or GRS reflecting insulin secretion. Further, an SNP (rs10824307) near LRMDA was uniquely associated with mild obesity-related diabetes. Therefore, we conclude that the subtypes have partially distinct genetic backgrounds indicating etiological differences.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Dwivedi, Om PrakashUniversity of Helsinki (author)
  • Prasad, Rashmi BLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)med-rpa (author)
  • Käräjämäki, AnnemariVaasa Central Hospital (author)
  • Hjort, RebeckaKarolinska Institute (author)
  • Thangam, ManonanthiniLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)ma4145th (author)
  • Åkerlund, MikaelLund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups(Swepub:lu)medk-mak (author)
  • Mahajan, AnubhaUniversity of Oxford (author)
  • Udler, Miriam SMassachusetts General Hospital (author)
  • Florez, Jose CMassachusetts General Hospital (author)
  • McCarthy, Mark IUniversity of Oxford (author)
  • Brosnan, JuliaPfizer Limited, UK (author)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
  • Carlsson, SofiaKarolinska Institutet,Karolinska Institute (author)
  • Hansson, OlaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)medk-oha (author)
  • Tuomi, TiinamaijaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Helsinki University Central Hospital,University of Helsinki,Folkhälsan Research Center(Swepub:lu)ti8736tu (author)
  • Groop, LeifLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr (author)
  • Ahlqvist, EmmaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups(Swepub:lu)infl-eah (author)
  • Translationell muskelforskningForskargrupper vid Lunds universitet (creator_code:org_t)
  • Regeneron Genetics Center

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC53, s. 1534-15421546-17181061-4036

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