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Assessing the Costs...
Assessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics Cohort Using Multistate Modeling
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- Clarke, Ann E. (author)
- University of Calgary
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- Hanly, John G. (author)
- Dalhousie University
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- Urowitz, Murray B. (author)
- University of Toronto
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- St. Pierre, Yvan (author)
- McGill University Health Center
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- Gordon, Caroline (author)
- University of Birmingham
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- Bae, Sang Cheol (author)
- Hanyang University Hospital for Rheumatic Disease
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- Romero-Diaz, Juanita (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Sanchez-Guerrero, Jorge (author)
- University of Toronto
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- Bernatsky, Sasha (author)
- McGill University Health Center
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- Wallace, Daniel J. (author)
- University of California, Los Angeles
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- Isenberg, David A. (author)
- University College London
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- Rahman, Anisur (author)
- University College London
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- Merrill, Joan T. (author)
- Oklahoma Medical Research Foundation
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- Fortin, Paul R. (author)
- Centre hospitalier universitaire de Québec
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- Gladman, Dafna D. (author)
- University of Toronto
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- Bruce, Ian N. (author)
- Manchester Academic Health Science Centre
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
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- Ginzler, Ellen M. (author)
- SUNY Downstate Health Sciences University
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- Dooley, Mary Anne (author)
- University of North Carolina
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University
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- Manzi, Susan (author)
- Allegheny Health Network
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Alarcón, Graciela S. (author)
- University of Alabama
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- Van Vollenhoven, Ronald F. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Aranow, Cynthia (author)
- Feinstein Institute for Medical Research
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- Mackay, Meggan (author)
- Feinstein Institute for Medical Research
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- Ruiz-Irastorza, Guillermo (author)
- University of the Basque Country
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- Lim, S. Sam (author)
- Emory University
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- Inanc, Murat (author)
- Istanbul University
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- Kalunian, Kenneth C. (author)
- University of California, San Diego
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- Jacobsen, Soren (author)
- Copenhagen University Hospital
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- Peschken, Christine A. (author)
- University of Manitoba
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- Kamen, Diane L. (author)
- Medical University of South Carolina
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- Askanase, Anca (author)
- Indian Institute of Technology
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- Farewell, Vernon (author)
- University of Cambridge
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(creator_code:org_t)
- 2023-02-23
- 2023
- English.
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In: Arthritis Care and Research. - : Wiley. - 2151-464X .- 2151-4658. ; 75:9, s. 1859-1870
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Objective: To estimate direct and indirect costs associated with neuropsychiatric (NP) events in the Systemic Lupus International Collaborating Clinics inception cohort. Methods: NP events were documented annually using American College of Rheumatology definitions for NP events and attributed to systemic lupus erythematosus (SLE) or non-SLE causes. Patients were stratified into 1 of 3 NP states (no, resolved, or new/ongoing NP event). Change in NP status was characterized by interstate transition rates using multistate modeling. Annual direct costs and indirect costs were based on health care use and impaired productivity over the preceding year. Annual costs associated with NP states and NP events were calculated by averaging all observations in each state and adjusted through random-effects regressions. Five- and 10-year costs for NP states were predicted by multiplying adjusted annual costs per state by expected state duration, forecasted using multistate modeling. Results: A total of 1,697 patients (49% White race/ethnicity) were followed for a mean of 9.6 years. NP events (n = 1,971) occurred in 956 patients, 32% attributed to SLE. For SLE and non-SLE NP events, predicted annual, 5-, and 10-year direct costs and indirect costs were higher in new/ongoing versus no events. Direct costs were 1.5-fold higher and indirect costs 1.3-fold higher in new/ongoing versus no events. Indirect costs exceeded direct costs 3.0 to 5.2 fold. Among frequent SLE NP events, new/ongoing seizure disorder and cerebrovascular disease accounted for the largest increases in annual direct costs. For non-SLE NP events, new/ongoing polyneuropathy accounted for the largest increase in annual direct costs, and new/ongoing headache and mood disorder for the largest increases in indirect costs. Conclusion: Patients with new/ongoing SLE or non-SLE NP events incurred higher direct and indirect costs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Clarke, Ann E.
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Hanly, John G.
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Urowitz, Murray ...
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St. Pierre, Yvan
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Gordon, Caroline
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Bae, Sang Cheol
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show more...
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Romero-Diaz, Jua ...
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Sanchez-Guerrero ...
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Bernatsky, Sasha
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Wallace, Daniel ...
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Isenberg, David ...
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Rahman, Anisur
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Merrill, Joan T.
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Fortin, Paul R.
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Gladman, Dafna D ...
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Bruce, Ian N.
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Petri, Michelle
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Ginzler, Ellen M ...
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Dooley, Mary Ann ...
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Ramsey-Goldman, ...
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Manzi, Susan
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Jönsen, Andreas
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Alarcón, Graciel ...
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Van Vollenhoven, ...
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Aranow, Cynthia
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Mackay, Meggan
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Ruiz-Irastorza, ...
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Lim, S. Sam
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Inanc, Murat
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Kalunian, Kennet ...
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Jacobsen, Soren
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Peschken, Christ ...
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Kamen, Diane L.
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Askanase, Anca
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Farewell, Vernon
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- MEDICAL AND HEALTH SCIENCES
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Arthritis Care a ...
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Lund University