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Sex differences in ...
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Wood, Madeline E.University of Toronto,Sunnybrook Health Sciences Centre
(författare)
Sex differences in associations between APOE ε2 and longitudinal cognitive decline
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:lup.lub.lu.se:6fbb2a47-e96e-4aa3-b61f-f330c7d04464
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https://lup.lub.lu.se/record/6fbb2a47-e96e-4aa3-b61f-f330c7d04464URI
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https://doi.org/10.1002/alz.13036DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately. RESULTS: In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajectories did not differ between sexes. There were no sex-specific associations of APOE ε2 with cognition in NHB participants (N = 2010). DISCUSSION: In NHW adults, APOE ε2 may protect men but not women against cognitive decline. Highlights: We studied sex-specific apolipoprotein E (APOE) ε2 effects on cognitive decline. In non-Hispanic White (NHW) adults, APOE ε2 selectively protects men against decline. Among men, APOE ε2 was more protective than APOE ε3/ε3. In women, APOE ε2 was no more protective than APOE ε3/ε3. Among APOE ε2 carriers, men had slower decline than women. There were no sex-specific APOE ε2 effects in non-Hispanic Black (NHB) adults.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Xiong, Lisa Y.University of Toronto,Sunnybrook Health Sciences Centre
(författare)
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Wong, Yuen YanUniversity of Toronto,Sunnybrook Health Sciences Centre
(författare)
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Buckley, Rachel F.Melbourne School of Psychological Sciences,Harvard Medical School,University of Melbourne
(författare)
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Swardfager, WalterSunnybrook Health Sciences Centre,University of Toronto
(författare)
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Masellis, MarioSunnybrook Health Sciences Centre,University of Toronto
(författare)
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Lim, Andrew S.P.University of Toronto,Sunnybrook Health Sciences Centre
(författare)
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Nichols, EmmaJohns Hopkins Bloomberg School of Public Health
(författare)
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Joie, Renaud LaUniversity of California, San Francisco
(författare)
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Casaletto, Kaitlin B.University of California, San Francisco
(författare)
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Kumar, Raj G.Icahn School of Medicine at Mount Sinai
(författare)
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Dams-O'Connor, KristenIcahn School of Medicine at Mount Sinai
(författare)
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Palta, PriyaColumbia University
(författare)
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George, Kristen M.University of California, Davis
(författare)
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Satizabal, Claudia L.Boston University,University of Texas Health Science Centre
(författare)
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Barnes, Lisa L.Rush Alzheimer's Disease Center
(författare)
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Schneider, Julie A.Rush Alzheimer's Disease Center
(författare)
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Binet, Alexa PichetteLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)al1314pi
(författare)
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Villeneuve, SylviaMcConnell Brain Imaging Centre,McGill University
(författare)
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Pa, JudyUniversity of Southern California
(författare)
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Brickman, Adam M.Columbia University
(författare)
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Black, Sandra E.Sunnybrook Health Sciences Centre,University of Toronto
(författare)
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Rabin, Jennifer S.University of Toronto,Sunnybrook Health Sciences Centre
(författare)
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University of TorontoSunnybrook Health Sciences Centre
(creator_code:org_t)
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ADNI and Prevent-AD Research Groups
Sammanhörande titlar
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Ingår i:Alzheimer's and Dementia: Wiley19:10, s. 4651-46611552-52601552-5279
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Wood, Madeline E ...
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Xiong, Lisa Y.
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Wong, Yuen Yan
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Buckley, Rachel ...
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Swardfager, Walt ...
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Masellis, Mario
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visa fler...
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Lim, Andrew S.P.
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Nichols, Emma
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Joie, Renaud La
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Casaletto, Kaitl ...
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Kumar, Raj G.
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Dams-O'Connor, K ...
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Palta, Priya
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George, Kristen ...
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Satizabal, Claud ...
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Barnes, Lisa L.
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Schneider, Julie ...
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Binet, Alexa Pic ...
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Villeneuve, Sylv ...
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Pa, Judy
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Brickman, Adam M ...
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Black, Sandra E.
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Rabin, Jennifer ...
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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