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  • Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam,Amsterdam Neuroscience (author)

Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-11-10
  • Springer Science and Business Media LLC,2022
  • 7 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:708ac86f-22eb-4397-a375-420c089e86b5
  • https://lup.lub.lu.se/record/708ac86f-22eb-4397-a375-420c089e86b5URI
  • https://doi.org/10.1038/s41591-022-02049-xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their cognition over time or are destined to decline. In this large multicenter amyloid and tau positron emission tomography (PET) study (n = 1,325), we examined the risk for future progression to mild cognitive impairment and the rate of cognitive decline over time among cognitively unimpaired individuals who were amyloid PET-positive (A+) and tau PET-positive (T+) in the medial temporal lobe (A+TMTL+) and/or in the temporal neocortex (A+TNEO-T+) and compared them with A+T- and A-T- groups. Cox proportional-hazards models showed a substantially increased risk for progression to mild cognitive impairment in the A+TNEO-T+ (hazard ratio (HR) = 19.2, 95% confidence interval (CI) = 10.9-33.7), A+TMTL+ (HR = 14.6, 95% CI = 8.1-26.4) and A+T- (HR = 2.4, 95% CI = 1.4-4.3) groups versus the A-T- (reference) group. Both A+TMTL+ (HR = 6.0, 95% CI = 3.4-10.6) and A+TNEO-T+ (HR = 7.9, 95% CI = 4.7-13.5) groups also showed faster clinical progression to mild cognitive impairment than the A+T- group. Linear mixed-effect models indicated that the A+TNEO-T+ (β = -0.056 ± 0.005, T = -11.55, P < 0.001), A+TMTL+ (β = -0.024 ± 0.005, T = -4.72, P < 0.001) and A+T- (β = -0.008 ± 0.002, T = -3.46, P < 0.001) groups showed significantly faster longitudinal global cognitive decline compared to the A-T- (reference) group (all P < 0.001). Both A+TNEO-T+ (P < 0.001) and A+TMTL+ (P = 0.002) groups also progressed faster than the A+T- group. In summary, evidence of advanced Alzheimer's disease pathological changes provided by a combination of abnormal amyloid and tau PET examinations is strongly associated with short-term (that is, 3-5 years) cognitive decline in cognitively unimpaired individuals and is therefore of high clinical relevance.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pichet Binette, AlexaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)al1314pi (author)
  • Groot, ColinLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam,Amsterdam Neuroscience(Swepub:lu)co1654gr (author)
  • Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-rsm (author)
  • Strandberg, OlofLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)teor-osn (author)
  • Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-spa (author)
  • Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-esr (author)
  • Tideman, PontusLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)po1670pa (author)
  • Ohlsson, TomasSkåne University Hospital (author)
  • Jögi, JonasSkåne University Hospital(Swepub:lu)klin-jjo (author)
  • Johnson, KeithHarvard Medical School,Massachusetts General Hospital (author)
  • Sperling, ReisaMassachusetts General Hospital,Harvard Medical School (author)
  • Dore, VincentAustin Health,CSIRO E-Health Research Center (author)
  • Masters, Colin LThe Florey Institute of Neuroscience and Mental Health (author)
  • Rowe, ChristopherThe Florey Institute of Neuroscience and Mental Health,Austin Health (author)
  • Visser, DeniseAmsterdam Neuroscience,Vrije Universiteit Amsterdam (author)
  • van Berckel, Bart N MAmsterdam Neuroscience,Vrije Universiteit Amsterdam (author)
  • van der Flier, Wiesje MAmsterdam Neuroscience,Vrije Universiteit Amsterdam (author)
  • Baker, SuzanneLawrence Berkeley National Laboratory (author)
  • Jagust, William JLawrence Berkeley National Laboratory,University of California, Berkeley (author)
  • Wiste, Heather JMayo Clinic Minnesota (author)
  • Petersen, Ronald CMayo Clinic Minnesota (author)
  • Jack, Clifford RMayo Clinic Minnesota (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
  • Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Nature Medicine: Springer Science and Business Media LLC28:11, s. 2381-23871546-170X1078-8956

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