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Amyloid and tau PET...
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam Neuroscience,Vrije Universiteit Amsterdam
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- Pichet Binette, Alexa (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Groot, Colin (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam Neuroscience,Vrije Universiteit Amsterdam
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- Smith, Ruben (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Strandberg, Olof (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Palmqvist, Sebastian (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Stomrud, Erik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Tideman, Pontus (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Ohlsson, Tomas (author)
- Skåne University Hospital
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- Jögi, Jonas (author)
- Skåne University Hospital
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- Johnson, Keith (author)
- Massachusetts General Hospital,Harvard Medical School
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- Sperling, Reisa (author)
- Harvard Medical School,Massachusetts General Hospital
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- Dore, Vincent (author)
- Austin Health,CSIRO E-Health Research Center
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- Masters, Colin L (author)
- The Florey Institute of Neuroscience and Mental Health
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- Rowe, Christopher (author)
- Austin Health,The Florey Institute of Neuroscience and Mental Health
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- Visser, Denise (author)
- Vrije Universiteit Amsterdam,Amsterdam Neuroscience
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- van Berckel, Bart N M (author)
- Vrije Universiteit Amsterdam,Amsterdam Neuroscience
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- van der Flier, Wiesje M (author)
- Amsterdam Neuroscience,Vrije Universiteit Amsterdam
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- Baker, Suzanne (author)
- Lawrence Berkeley National Laboratory
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- Jagust, William J (author)
- University of California, Berkeley,Lawrence Berkeley National Laboratory
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- Wiste, Heather J (author)
- Mayo Clinic Minnesota
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- Petersen, Ronald C (author)
- Mayo Clinic Minnesota
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- Jack, Clifford R (author)
- Mayo Clinic Minnesota
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2022-11-10
- 2022
- English 7 s.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 28:11, s. 2381-2387
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Abstract
Subject headings
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- A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their cognition over time or are destined to decline. In this large multicenter amyloid and tau positron emission tomography (PET) study (n = 1,325), we examined the risk for future progression to mild cognitive impairment and the rate of cognitive decline over time among cognitively unimpaired individuals who were amyloid PET-positive (A+) and tau PET-positive (T+) in the medial temporal lobe (A+TMTL+) and/or in the temporal neocortex (A+TNEO-T+) and compared them with A+T- and A-T- groups. Cox proportional-hazards models showed a substantially increased risk for progression to mild cognitive impairment in the A+TNEO-T+ (hazard ratio (HR) = 19.2, 95% confidence interval (CI) = 10.9-33.7), A+TMTL+ (HR = 14.6, 95% CI = 8.1-26.4) and A+T- (HR = 2.4, 95% CI = 1.4-4.3) groups versus the A-T- (reference) group. Both A+TMTL+ (HR = 6.0, 95% CI = 3.4-10.6) and A+TNEO-T+ (HR = 7.9, 95% CI = 4.7-13.5) groups also showed faster clinical progression to mild cognitive impairment than the A+T- group. Linear mixed-effect models indicated that the A+TNEO-T+ (β = -0.056 ± 0.005, T = -11.55, P < 0.001), A+TMTL+ (β = -0.024 ± 0.005, T = -4.72, P < 0.001) and A+T- (β = -0.008 ± 0.002, T = -3.46, P < 0.001) groups showed significantly faster longitudinal global cognitive decline compared to the A-T- (reference) group (all P < 0.001). Both A+TNEO-T+ (P < 0.001) and A+TMTL+ (P = 0.002) groups also progressed faster than the A+T- group. In summary, evidence of advanced Alzheimer's disease pathological changes provided by a combination of abnormal amyloid and tau PET examinations is strongly associated with short-term (that is, 3-5 years) cognitive decline in cognitively unimpaired individuals and is therefore of high clinical relevance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Humans
- Alzheimer Disease/pathology
- tau Proteins/metabolism
- Brain/metabolism
- Cognitive Dysfunction/diagnostic imaging
- Positron-Emission Tomography/methods
- Amyloid/metabolism
- Amyloid beta-Peptides/metabolism
- Amyloidosis
- Plaque, Amyloid
- Biomarkers
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ossenkoppele, Ri ...
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Pichet Binette, ...
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Groot, Colin
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Smith, Ruben
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Strandberg, Olof
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Palmqvist, Sebas ...
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show more...
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Stomrud, Erik
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Tideman, Pontus
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Ohlsson, Tomas
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Jögi, Jonas
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Johnson, Keith
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Sperling, Reisa
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Dore, Vincent
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Masters, Colin L
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Rowe, Christophe ...
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Visser, Denise
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van Berckel, Bar ...
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van der Flier, W ...
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Baker, Suzanne
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Jagust, William ...
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Wiste, Heather J
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Petersen, Ronald ...
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Jack, Clifford R
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Hansson, Oskar
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and Clinical Medicin ...
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and Neurology
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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Nature Medicine
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Lund University