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Dietary Glycemic In...
Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes : A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies
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- Livesey, Geoffrey (author)
- Independent Nutrition Logic Ltd
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- Taylor, Richard (author)
- Independent Nutrition Logic Ltd
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- Livesey, Helen F. (author)
- Independent Nutrition Logic Ltd
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- Buyken, Anette E. (author)
- University of Paderborn
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- Jenkins, David J.A. (author)
- Saint Michael's Hospital,University of Toronto
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- Augustin, Livia S.A. (author)
- Istituto Nazionale Tumori IRCCS - Fondazione G Pascale, Napoli,Saint Michael's Hospital
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- Sievenpiper, John L. (author)
- University of Toronto,Saint Michael's Hospital
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- Barclay, Alan W. (author)
- Glycemic Index Foundation
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- Liu, Simin (author)
- Brown University
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- Wolever, Thomas M.S. (author)
- University of Toronto,Saint Michael's Hospital
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- Willett, Walter C. (author)
- Harvard University
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- Brighenti, Furio (author)
- University of Parma
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- Salas-Salvadó, Jordi (author)
- Rovira i Virgili University (URV),Carlos III Health Institute
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- Björck, Inger (author)
- Lund University,Lunds universitet,Centrum för preventiv livsmedelsforskning, Medicon Village,Universitetets särskilda verksamheter,Food for Health Science Centre, Medicon Village,University Specialised Centres
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- Rizkalla, Salwa W. (author)
- Pitié-Salpêtrière University Hospital
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- Riccardi, Gabriele (author)
- University of Naples Federico II
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- La Vecchia, Carlo (author)
- University of Milan
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- Ceriello, Antonio (author)
- IRCCS Multimedica
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens
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- Poli, Andrea (author)
- Nutrition Foundation of Italy
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- Astrup, Arne (author)
- University of Copenhagen
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- Kendall, Cyril W.C. (author)
- University of Toronto,University of Saskatchewan,Saint Michael's Hospital
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- Ha, Marie Ann (author)
- Oldways/ Whole Grains Council
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- Baer-Sinnott, Sara (author)
- Oldways/ Whole Grains Council
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- Brand-Miller, Jennie C. (author)
- University of Sydney
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(creator_code:org_t)
- 2019-06-05
- 2019
- English.
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In: Nutrients. - : MDPI AG. - 2072-6643. ; 11:6
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://doi.org/10.3...
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Abstract
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- Published meta-analyses indicate significant but inconsistent incident type-2 diabetes(T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is nowover a decade ago that a published meta-analysis used a predefined standard to identify validstudies. Considering valid studies only, and using random effects dose-response meta-analysis(DRM) while withdrawing spurious results (p < 0.05), we ascertained whether these relationswould support nutrition guidance, specifically for an RR > 1.20 with a lower 95% confidence limit>1.10 across typical intakes (approximately 10th to 90th percentiles of population intakes). Thecombined T2D-GI RR was 1.27 (1.15-1.40) (p < 0.001, n = 10 studies) per 10 units GI, while that forthe T2D-GL RR was 1.26 (1.15-1.37) (p < 0.001, n = 15) per 80 g/d GL in a 2000 kcal (8400 kJ) diet.The corresponding global DRM using restricted cubic splines were 1.87 (1.56-2.25) (p < 0.001, n =10) and 1.89 (1.66-2.16) (p < 0.001, n = 15) from 47.6 to 76.1 units GI and 73 to 257 g/d GL in a 2000kcal diet, respectively. In conclusion, among adults initially in good health, diets higher in GI or GLwere robustly associated with incident T2D. Together with mechanistic and other data, thissupports that consideration should be given to these dietary risk factors in nutrition advice.Concerning the public health relevance at the global level, our evidence indicates that GI and GLare substantial food markers predicting the development of T2D worldwide, for persons ofEuropean ancestry and of East Asian ancestry.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- alcohol
- cohort studies
- dietary fiber
- epidemiology
- glycemic index
- glycemic load
- meta-analysis
- protein
- type 2 diabetes
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Livesey, Geoffre ...
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Taylor, Richard
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Livesey, Helen F ...
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Buyken, Anette E ...
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Jenkins, David J ...
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Augustin, Livia ...
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Sievenpiper, Joh ...
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Barclay, Alan W.
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Liu, Simin
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Wolever, Thomas ...
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Willett, Walter ...
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Brighenti, Furio
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Salas-Salvadó, J ...
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Björck, Inger
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Rizkalla, Salwa ...
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Riccardi, Gabrie ...
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La Vecchia, Carl ...
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Ceriello, Antoni ...
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Trichopoulou, An ...
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Poli, Andrea
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Astrup, Arne
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Kendall, Cyril W ...
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Ha, Marie Ann
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Baer-Sinnott, Sa ...
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Brand-Miller, Je ...
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Nutrients
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Lund University