Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines

• The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.

Ämnesord

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Nyckelord

amines

copper

enamines

enantioselectivity

hydroamination

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)