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DNA methylation ris...
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Linares-Pineda, Teresa MUniversity of Granada
(author)
DNA methylation risk score for type 2 diabetes is associated with gestational diabetes
- Article/chapterEnglish2024
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LIBRIS-ID:oai:lup.lub.lu.se:722cc279-3c38-4fcc-946a-34b6795de576
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https://lup.lub.lu.se/record/722cc279-3c38-4fcc-946a-34b6795de576URI
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https://doi.org/10.1186/s12933-024-02151-zDOI
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Language:English
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Summary in:English
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BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM.RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM: odd ratio (OR)[95% CI]: 1.3 [1.1-1.8], P = 0.002 for the unadjusted model, and 1.4 [1.1-1.7], P = 0.00014 for a model adjusted by age, pre-pregnant BMI, family history of diabetes and smoking status. Also, we found 6 CpGs through a meta-analysis (cg14020176, cg22650271, cg14870271, cg27243685, cg06378491, cg25130381) associated with GDM, and some of their methylation quantitative loci (mQTLs) were related to T2DM and GDM.CONCLUSION: For the first time, we show that DNA methylation marks for T2DM are also associated with GDM, suggesting shared epigenetic mechanisms between GDM and T2DM.
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Fragoso-Bargas, NicolasOslo university hospital(Swepub:lu)ni2035fr
(author)
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Picón, María JoséHospitales Regional Universitario y Virgen de la Victoria de Málaga
(author)
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Molina-Vega, MariaHospitales Regional Universitario y Virgen de la Victoria de Málaga
(author)
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Jenum, Anne KarenUniversity of Oslo
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Sletner, LineAkershus University Hospital
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Lee-Ødegård, SindreUniversity of Oslo
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Opsahl, Julia O.Haukeland University Hospital
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Moen, Gunn-HelenUniversity of Bristol
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Qvigstad, ElisabethOslo university hospital
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Prasad, Rashmi BLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki(Swepub:lu)med-rpa
(author)
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Birkeland, Kåre IOslo university hospital
(author)
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Morcillo, SonsolesHospitales Regional Universitario y Virgen de la Victoria de Málaga
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Sommer, ChristineOslo university hospital
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University of GranadaOslo university hospital
(creator_code:org_t)
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In:Cardiovascular Diabetology231475-2840
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