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  • Lozano, ManuelUniversity of Valencia (author)

DNA methylation changes associated with prenatal mercury exposure : A meta-analysis of prospective cohort studies from PACE consortium

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier BV,2022

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:728be5ae-c0a1-42d4-920b-0c17c838381c
  • https://lup.lub.lu.se/record/728be5ae-c0a1-42d4-920b-0c17c838381cURI
  • https://doi.org/10.1016/j.envres.2021.112093DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147885973URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (β = 2.28 × 10−4, p-value = 5.87 × 10−5) in relation to prenatal MeHg exposure. In child blood, we identified differential DNAm at cg15288800 (β = 0.004, p-value = 4.97 × 10−5), also located in MED31. This repeated link to MED31, a gene involved in lipid metabolism and RNA Polymerase II transcription function, may suggest a DNAm perturbation related to MeHg exposure that persists into early childhood. Further, we found evidence for association between prenatal MeHg exposure and child blood DNAm levels at two additional CpGs: cg12204245 (β = 0.002, p-value = 4.81 × 10−7) in GRK1 and cg02212000 (β = −0.001, p-value = 8.13 × 10−7) in GGH. Prenatal MeHg exposure was associated with DNAm modifications that may influence health outcomes, such as cognitive or anthropometric development, in different populations.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Yousefi, PaulUniversity of Bristol (author)
  • Broberg, KarinKarolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups(Swepub:lu)kgen-kbr (author)
  • Soler-Blasco, RaquelUniversity of Valencia (author)
  • Miyashita, ChihiroHokkaido University (author)
  • Pesce, GiancarloCentre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay (author)
  • Kim, Woo JinKangwon National University (author)
  • Rahman, MohammadHarvard Pilgrim Health Care Institute,Harvard Medical School (author)
  • Bakulski, Kelly M.University of Michigan (author)
  • Haug, Line S.Norwegian Institute of Public Health (author)
  • Ikeda-Araki, AtsukoHokkaido University (author)
  • Huel, GuyUniversity of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP) (author)
  • Park, JaehyunSeoul National University (author)
  • Relton, CarolineUniversity of Bristol (author)
  • Vrijheid, MartinePompeu Fabra University,Centre for Research in Environmental Epidemiology (author)
  • Rifas-Shiman, SherylHarvard Medical School,Harvard Pilgrim Health Care Institute (author)
  • Oken, EmilyHarvard Pilgrim Health Care Institute,Harvard Medical School (author)
  • Dou, John F.University of Michigan (author)
  • Kishi, ReikoHokkaido University (author)
  • Gutzkow, Kristine B.Norwegian Institute of Public Health (author)
  • Annesi-Maesano, IsabellaUniversity of Montpellier (author)
  • Won, SunghoSeoul National University (author)
  • Hivert, Marie FranceMassachusetts General Hospital (author)
  • Fallin, M. DanieleJohns Hopkins Bloomberg School of Public Health (author)
  • Vafeiadi, MarinaUniversity of Crete Medical School (author)
  • Ballester, FerranUniversity of Valencia (author)
  • Bustamante, MarionaCentre for Research in Environmental Epidemiology,Pompeu Fabra University (author)
  • Llop, SabrinaUniversity of Valencia,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • University of ValenciaUniversity of Bristol (creator_code:org_t)

Related titles

  • In:Environmental Research: Elsevier BV2040013-93511096-0953

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