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  • Polonis, Victoria R (author)

Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:736d286c-42d8-475c-a593-806e48b56e80
  • https://lup.lub.lu.se/record/1201927URI
  • https://doi.org/10.1016/j.virol.2008.02.007DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:for swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • In AIDS vaccine development the pendulum has swung towards a renewed emphasis on the potential role for neutralizing antibodies in a successful global vaccine. It is recognized that vaccine-induced antibody performance, as assessed in the available neutralization assays, may well serve as a "gatekeeper" for HIV-1 subunit vaccine prioritization and advancement. As a result, development of a standardized platform for reproducible measurement of neutralizing antibodies has received considerable attention. Here we review current advancements in our knowledge of the performance of different types of antibodies in a traditional primary cell neutralization assay and the newer, more standardized TZM-bl reporter cell line assay. In light of recently revealed differences (see accompanying article) in the results obtained in these two neutralization formats, parallel evaluation with both platforms should be contemplated as an interim solution until a better understanding of immune correlates of protection is achieved.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Brown, Bruce K (author)
  • Borges, Andrew Rosa (author)
  • Zolla-Pazner, Susan (author)
  • Dimitrov, Dimiter S (author)
  • Zhang, Mei-Yun (author)
  • Barnett, Susan W (author)
  • Ruprecht, Ruth M (author)
  • Scarlatti, Gabriella (author)
  • Fenyö, Eva MariaLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-emf (author)
  • Montefiori, David C (author)
  • McCutchan, Francine E (author)
  • Michael, Nelson L (author)
  • Avdelningen för medicinsk mikrobiologiInstitutionen för laboratoriemedicin (creator_code:org_t)

Related titles

  • In:Virology: Elsevier BV375:2, s. 315-3201096-03410042-6822

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  • Virology (Search for host publication in LIBRIS)

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