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Correlation of plas...
Correlation of plasma coagulation parameters with thromboprophylaxis, patient characteristics, and outcome in the MEDENOX study
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Desjardins, L (författare)
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Bara, L (författare)
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Boutitie, F (författare)
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Samama, MM (författare)
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Cohen, AT (författare)
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Combe, S (författare)
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Janbon, C (författare)
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Leizorovicz, A (författare)
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- Olsson, Carl-Gustav (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Turpie, AGG (författare)
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(creator_code:org_t)
- 2004
- 2004
- Engelska.
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Ingår i: Archives of pathology & laboratory medicine. - 0003-9985. ; 128:5, s. 519-526
- Relaterad länk:
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http://www.archiveso...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- 0 Context.-Plasma anti-Xa and anti-IIa activities correlate with the dose of low-molecular-weight heparin, and D-dimer and thrombin-antithrombin complexes are markers of procoagulant activity. Objective.-To investigate the relationship between plasma coagulation parameters and patient characteristics, including renal function, thromboprophylaxis, and incidence of venous thromboembolism (VTE) in the MEDENOX study population. Design.-Controlled, multicenter, double-blind, randomized study. Patients.-Two hundred twenty-four acutely ill medical patients. Interventions.-Either 20 or 40 mg of enoxaparin administered subcutaneously or a placebo once daily for 10 (+/-4) days. ain Outcome Measures.-VTE and plasma anti-Xa and anti-IIa activities, D-dimer, and thrombin-antithrombin levels in blood collected before prophylaxis was given (day 0) and after the last injection of the study drug. Results and Conclusions.-Anti-Xa activity correlated with the dose of enoxaparin. In patients with mild or moderate renal impairment, there was no significant relationship between anti-Xa activity and the creatinine clearance rate. D-dimer concentrations were lower at day 10 (+/-4) in the 40-mg group, which had a 63% lower VTE incidence, than at day 0. No venographically confirmed thromboses were found in patients with a normal D-dimer I concentration (<0.5 mug/mL [0.5 mg/L]). D-dimer levels were higher in patients with VTE than in those without VTE, but no predictive value could be demonstrated for individual patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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Desjardins, L
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Bara, L
-
Boutitie, F
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Samama, MM
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Cohen, AT
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Combe, S
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visa fler...
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Janbon, C
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Leizorovicz, A
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Olsson, Carl-Gus ...
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Turpie, AGG
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visa färre...
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