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- Haglund, CeciliaKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)
An intraosseous myoepithelial carcinoma with a EWSR1::PBX3 fusion
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- WILEY,2023
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-194162
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-194162URI
- https://doi.org/10.1002/gcc.23148DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:152597163URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Herein we report a case of an intraosseous myoepithelial carcinoma harboring a EWSR1::PBX3 fusion gene. The patient was a 64-year-old male found to have a 7 cm destructive lesion in the distal ulna with an extraosseous soft tissue component. Microscopic examination of the resected tumor showed a spindle-cell lesion within a sclerotic stroma and intravascular tumor emboli. At higher power the tumor cells showed moderate nuclear atypia with a high mitotic count (20 per mm(2)). Immunohistochemistry revealed diffuse EMA positivity and focal pancytokeratin (AE1/AE3) and S100 expression, consistent with myoepithelial differentiation. NGS using the Oncomine Childhood Cancer Assay (Thermo Fisher Scientific, Inc.) revealed a EWSR1-PBX3 fusion and ABL amplification. The patient subsequently developed local recurrence as well as distant lymph node, lung and vertebral metastases; he is currently awaiting systemic treatment in the context of a clinical trial. In this report, we present a rare case of a skeletal myoepithelial tumor harboring a EWSR1::PBX3 fusion with demonstrated histological and clinical features of malignancy.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- EWSR1; myoepithelial carcinoma; PBX3
Added entries (persons, corporate bodies, meetings, titles ...)
- Zemmler, MajaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)mejze51 (author)
- Tsagkozis, PanagiotisKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)
- Haglund de Flon, FelixKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)
- Karolinska InstitutetKarolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (creator_code:org_t)
Related titles
- In:Genes, Chromosomes and Cancer: WILEY62:10, s. 607-6101045-22571098-2264
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