Effect of assisted walking-movement in patients with genetic and acquired neuromuscular disorders with the motorised Innowalk device : an international case study meta-analysis

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MARC

Schmidt-Lucke, CMEDIACC GmbH,Charité - University Medicine Berlin (author)

Effect of assisted walking-movement in patients with genetic and acquired neuromuscular disorders with the motorised Innowalk device : an international case study meta-analysis

Article/chapterEnglish2019

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2019-06-18
PeerJ,2019

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LIBRIS-ID:oai:lup.lub.lu.se:740b2a08-d549-4327-b28f-917d92845805
https://lup.lub.lu.se/record/740b2a08-d549-4327-b28f-917d92845805URI
https://doi.org/10.7717/peerj.7098DOI

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Language:English
Summary in:English

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People with physical disabilities (PD) suffer from consequences due to lack of physical activity and consequently, are at increased risk of chronic diseases. We aimed to evaluate the ability of a motorised assistive device for dynamic standing with weight-bearing in addition to standard state-of-the-art therapy to improve clinical outcome in a meta-analysis of available studies. A total of 11 studies were identified from different European countries analysing the effect of the dynamic device Innowalk. Raw data of nine studies were pooled including a total of 31 patients observed between 2009 and 2017. Standardised questionnaires and physical outcomes were examined in this exploratory meta-analysis. We recorded patients' characteristics, duration, intensity, and location of usage as well as general clinical outcomes and improvement of passive range of motion (PROM). The analysed population consisted in 90% cases of patients younger than 18 years of age. Patients were severely disabled individuals (aged 8 (6-10) years; 58% male; 67% non-ambulatory, 86% cerebral palsy). A total of 94% used the Innowalk in a home-based or day-care setting. For nearly all individuals (94%), improvements were recorded for: walking or weight-bearing transfer (n = 13), control/strength of the trunk or head (n = 6), joint mobility (n = 14), sleep (n = 4 out of 6/67%), or muscle strength (n = 17), vital functions (n = 16), bowel function (n = 10), attention/orientation (n = 2). PROM of the hip (flexion, abduction, and adduction) significantly (p < 0.001 for multiple comparisons) increased after 1 month (p < 0.05 flexion, adduction) and further after 5 months (p < 0.05 each) in contrast (p < 0.05 each) to a control group with state-of-the-art therapy. Similarly, PROM showed a trend towards improvement in dorsal extension of the ankle (p = 0.07). In summary, this is the first report of a novel device with additional benefit to standard therapy for severe PD. These intriguing results warrant the planned prospective randomised controlled trial to prove the concept and mechanism of action of this device.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Sjukgymnastik hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Physiotherapy hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Käferle, JDanube University Krems (author)
Rydh Berner, BMDanderyd Hospital (author)
Ahlborg, LDanderyd Hospital (author)
Hansen, HMUniversity of Bergen (author)
Skjellvik Tollefsen, UAsker kommune (author)
Thon, TPorsgrunn kommune (author)
Damkjaer Moen, RMade for Movement (author)
Pekanovic, AMEDIACC GmbH (author)
Tornberg, ÅsaLund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups(Swepub:lu)fhv-ase (author)
Lauruschkus, KatarinaLund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups(Swepub:lu)med-klh (author)
MEDIACC GmbHCharité - University Medicine Berlin (creator_code:org_t)

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In:PeerJ: PeerJ7, s. 7098-70982167-8359

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By the author/editor: Schmidt-Lucke, C; Käferle, J; Rydh Berner, BM; Ahlborg, L; Hansen, HM; Skjellvik Tollef ...; show more...; Thon, T; Damkjaer Moen, R; Pekanovic, A; Tornberg, Åsa; Lauruschkus, Kat ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Physiotherapy

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