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Anthropometric Meas...
Anthropometric Measures, Body Mass Index, and Pancreatic Cancer A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)
- Article/chapterEnglish2010
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LIBRIS-ID:oai:lup.lub.lu.se:7423072f-debc-44a5-94c9-075b74888d57
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https://lup.lub.lu.se/record/1618915URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association, between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese, >= 35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58; P-trend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69; P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70; P-trend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women. Arch Intern Med. 2010;170(9):791 -802
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Added entries (persons, corporate bodies, meetings, titles ...)
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Helzlsouer, Kathy J.
(author)
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Kooperberg, Charles
(author)
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Shu, Xiao-Ou
(author)
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Steplowski, Emily
(author)
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Bueno-de-Mesquita, H. Bas
(author)
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Fuchs, Charles S.
(author)
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Gross, Myron D.
(author)
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Jacobs, Eric J.
(author)
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LaCroix, Andrea Z.
(author)
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Petersen, Gloria M.
(author)
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Stolzenberg-Solomon, Rachael Z.
(author)
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Zheng, Wei
(author)
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Albanes, Demetrius
(author)
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Amundadottir, Laufey
(author)
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Bamlet, William R.
(author)
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Barricarte, Aurelio
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Bingham, Sheila A.
(author)
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Boeing, Heiner
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Buring, Julie E.
(author)
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Chanock, Stephen J.
(author)
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Clipp, Sandra
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Gaziano, J. Michael
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Giovannucci, Edward L.
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Hankinson, Susan E.
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Hartge, Patricia
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Hoover, Robert N.
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Hunter, David J.
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Hutchinson, Amy
(author)
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Jacobs, Kevin B.
(author)
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Kraft, Peter
(author)
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Lynch, Shannon M.
(author)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)smi-jma
(author)
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Manson, JoAnn E.
(author)
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McTiernan, Anne
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McWilliams, Robert R.
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Mendelsohn, Julie B.
(author)
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Michaud, Dominique S.
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Palli, Domenico
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Rohan, Thomas E.
(author)
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Slimani, Nadia
(author)
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Thomas, Gilles
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Tjonneland, Anne
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Tobias, Geoffrey S.
(author)
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Trichopoulos, Ditnitrios
(author)
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Virtamo, Jarmo
(author)
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Wolpin, Brian M.
(author)
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Yu, Kai
(author)
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Zeleniuch-Jacquotte, Anne
(author)
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Patel, Alpa V.
(author)
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KirurgiForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Archives of Internal Medicine170:9, s. 791-8020003-9926
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Arslan, Alan A.
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Helzlsouer, Kath ...
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Kooperberg, Char ...
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Shu, Xiao-Ou
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Steplowski, Emil ...
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Bueno-de-Mesquit ...
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Fuchs, Charles S ...
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Gross, Myron D.
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Jacobs, Eric J.
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LaCroix, Andrea ...
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Petersen, Gloria ...
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Stolzenberg-Solo ...
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Zheng, Wei
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Albanes, Demetri ...
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Amundadottir, La ...
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Bamlet, William ...
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Barricarte, Aure ...
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Bingham, Sheila ...
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Boeing, Heiner
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Boutron-Ruault, ...
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Buring, Julie E.
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Chanock, Stephen ...
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Clipp, Sandra
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Gaziano, J. Mich ...
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Giovannucci, Edw ...
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Hankinson, Susan ...
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Hartge, Patricia
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Hoover, Robert N ...
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Hunter, David J.
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Hutchinson, Amy
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Jacobs, Kevin B.
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Kraft, Peter
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Lynch, Shannon M ...
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Manjer, Jonas
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Manson, JoAnn E.
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McTiernan, Anne
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McWilliams, Robe ...
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Mendelsohn, Juli ...
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Michaud, Dominiq ...
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Palli, Domenico
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Rohan, Thomas E.
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Slimani, Nadia
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Thomas, Gilles
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Tjonneland, Anne
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Tobias, Geoffrey ...
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Trichopoulos, Di ...
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Virtamo, Jarmo
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Wolpin, Brian M.
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Yu, Kai
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Zeleniuch-Jacquo ...
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Patel, Alpa V.
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