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Urinary N-acetyl-be...
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Agardh, Carl-DavidLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
(author)
Urinary N-acetyl-beta-D-glucosaminidase activity does not predict development of diabetic nephropathy
- Article/chapterEnglish1987
Publisher, publication year, extent ...
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American Diabetes Association,1987
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LIBRIS-ID:oai:lup.lub.lu.se:743a34fb-65ff-4310-b0af-fc80291c6c9d
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https://lup.lub.lu.se/record/1103829URI
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https://doi.org/10.2337/diacare.10.5.604DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Urinary activity of N-acetyl-beta-D-glucosaminidase (NAG) has been suggested as a marker for diabetic nephropathy. In this study, urinary activity of NAG was measured with an interval of 5 yr in 36 insulin-dependent diabetic subjects to evaluate its predictive value for development of diabetic nephropathy. During the observation period, 9 patients developed detectable signs of diabetic nephropathy. In these patients, urinary albumin concentration had increased to 503 +/- 185 mg/L, compared to 16 +/- 1 mg/L in patients without nephropathy (P less than .01; means +/- SE), and the fractional albumin excretion rate was 0.21 +/- 0.07 X 10(-3), compared to 0.01 +/- 0.00 X 10(-3) (P less than .01). However, the activity of urinary NAG was not different in these patients compared with the patients without nephropathy (0.69 +/- 0.15 and 0.61 +/- 0.09 U/mmol creatinine, respectively). Furthermore, no increase in the activity of urinary NAG was seen during the observation period in either group. We concluded that the urinary activity of NAG is not related to the development of microalbuminuria and therefore cannot be used as a predictor for the development of diabetic nephropathy.
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Tallroth, G
(author)
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Hultberg, B
(author)
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Institutionen för kliniska vetenskaper, MalmöMedicinska fakulteten
(creator_code:org_t)
Related titles
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In:Diabetes Care: American Diabetes Association10:5, s. 604-6061935-55480149-5992
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