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Pharmacological mod...
Pharmacological modulation of vascular ageing: a review from VascAgeNet
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- Roth, Lynn (författare)
- University of Antwerp
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- Dogan, Soner (författare)
- Yeditepe University
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- Tuna, Bilge guvenc (författare)
- Yeditepe University
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- Aranyi, Tamas (författare)
- Semmelweis University,Research Centre for Natural Sciences of the Hungarian Academy of Sciences
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- Benitez, Sonia (författare)
- Carlos III Health Institute
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- Borrell-Pages, Maria (författare)
- Carlos III Health Institute
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- Bozaykut, Perinur (författare)
- Acıbadem Mehmet Ali Aydınlar University
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- De meyer, Guido r.y. (författare)
- University of Antwerp
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- Duca, Laurent (författare)
- University Of Reims Champagne-Ardenne
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- Durmus, Nergiz (författare)
- Dokuz Eylül University
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- Fonseca, Diogo (författare)
- University of Coimbra
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- Fraenkel, Emil (författare)
- Technical University of Košice
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- Gillery, Philippe (författare)
- University Of Reims Champagne-Ardenne
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- Giudici, Alessandro (författare)
- Maastricht University
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- Jaisson, Stéphane (författare)
- University Of Reims Champagne-Ardenne
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- Johansson, Madeleine (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Julve, Josep (författare)
- Carlos III Health Institute
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- Lucas-Herald, Angela k. (författare)
- University of Glasgow
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- Martinet, Wim (författare)
- University of Antwerp
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- Maurice, Pascal (författare)
- University Of Reims Champagne-Ardenne
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- Mcdonnell, Barry (författare)
- Cardiff Metropolitan University
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- Ozbek, Emine nur (författare)
- Ege University
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- Pucci, Giacomo (författare)
- University of Perugia
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- Pugh, Christopher j.a. (författare)
- Cardiff Metropolitan University
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- Rochfort, Keith d. (författare)
- Dublin City University
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- Roks, Anton j.m. (författare)
- Erasmus University Rotterdam
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- Rotllan, Noemi (författare)
- Carlos III Health Institute
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- Shadiow, James (författare)
- University of Michigan
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- Sohrabi, Yahya (författare)
- University Hospital Münster,Charles University in Prague
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- Spronck, Bart (författare)
- Maastricht University,Macquarie University, Sydney
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- Szeri, Flora (författare)
- Research Centre for Natural Sciences of the Hungarian Academy of Sciences
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- Terentes-Printzios, Dimitrios (författare)
- National and Kapodistrian University of Athens
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- Aydın, Elif tunç (författare)
- Izmir Katip Celebi University
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- Tura-Ceide, Olga (författare)
- CIBER Enfermedades Respiratorias (CIBERES),University of Barcelona,Girona Biomedical Research Institute (IDIBGI)
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- Ucar, Eda (författare)
- Yeditepe University
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- Anacak, Gunay yetik (författare)
- Acıbadem Mehmet Ali Aydınlar University
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Ageing Research Reviews. - 1872-9649.
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- vascular ageing
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- ref (ämneskategori)
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Roth, Lynn
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Dogan, Soner
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Tuna, Bilge guve ...
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Aranyi, Tamas
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Benitez, Sonia
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Borrell-Pages, M ...
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Bozaykut, Perinu ...
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De meyer, Guido ...
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Duca, Laurent
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Durmus, Nergiz
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Fonseca, Diogo
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Fraenkel, Emil
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Gillery, Philipp ...
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Giudici, Alessan ...
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Jaisson, Stéphan ...
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Johansson, Madel ...
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Julve, Josep
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Lucas-Herald, An ...
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Martinet, Wim
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Maurice, Pascal
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Mcdonnell, Barry
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Ozbek, Emine nur
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Pucci, Giacomo
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Pugh, Christophe ...
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Rochfort, Keith ...
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Roks, Anton j.m.
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Rotllan, Noemi
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Shadiow, James
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Sohrabi, Yahya
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Spronck, Bart
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Szeri, Flora
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Terentes-Printzi ...
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Aydın, Elif tunç
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Tura-Ceide, Olga
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Ucar, Eda
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Anacak, Gunay ye ...
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