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  • Delfin, CarlNovo Nordisk A/S (author)

A Federated Database for Obesity Research : An IMI-SOPHIA Study

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • 2024

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:74bd0687-9fd0-433c-aa55-f7ae8cd24fd3
  • https://lup.lub.lu.se/record/74bd0687-9fd0-433c-aa55-f7ae8cd24fd3URI
  • https://doi.org/10.3390/life14020262DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challenges to achieving these goals is that many clinical cohorts are siloed, limiting the potential of combined data for biomarker discovery. In SOPHIA, we have addressed this challenge by setting up a federated database building on open-source DataSHIELD technology. The database currently federates 16 cohorts that are accessible via a central gateway. The database is multi-modal, including research studies, clinical trials, and routine health data, and is accessed using the R statistical programming environment where statistical and machine learning analyses can be performed at a distance without any disclosure of patient-level data. We demonstrate the use of the database by providing a proof-of-concept analysis, performing a federated linear model of BMI and systolic blood pressure, pooling all data from 16 studies virtually without any analyst seeing individual patient-level data. This analysis provided similar point estimates compared to a meta-analysis of the 16 individual studies. Our approach provides a benchmark for reproducible, safe federated analyses across multiple study types provided by multiple stakeholders.

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  • Dragan, IulianSwiss Institute for Bioinformatics (SIB) (author)
  • Kuznetsov, DmitrySwiss Institute for Bioinformatics (SIB) (author)
  • Tajes, Juan FernandezLund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)ju3355fe (author)
  • Smit, FemkeMaastricht University (author)
  • Coral, Daniel E.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)da1078co (author)
  • Farzaneh, AliErasmus University Medical Center (author)
  • Haugg, AndréBoehringer Ingelheim GmbH (author)
  • Hungele, AndreasGerman Center for Diabetes Research (author)
  • Niknejad, AnneSwiss Institute for Bioinformatics (SIB) (author)
  • Hall, ChristopherUniversity of Dundee (author)
  • Jacobs, Daan (author)
  • Marek, DianaSwiss Institute for Bioinformatics (SIB) (author)
  • Fraser, Diane P.University of Exeter (author)
  • Thuillier, Dorothee (author)
  • Ahmadizar, FaribaUniversity Medical Center Utrecht (author)
  • Mehl, FlorenceSwiss Institute for Bioinformatics (SIB) (author)
  • Pattou, Francois (author)
  • Burdet, FredericSwiss Institute for Bioinformatics (SIB) (author)
  • Hawkes, GarethUniversity of Exeter (author)
  • Arts, Ilja C.W.Maastricht University (author)
  • Blanch, JordiCatalan Institute Of Health (author)
  • Van Soest, JohanMaastricht University,Yukioka Hospital (author)
  • Fernández-Real, José ManuelGirona Biomedical Research Institute (IDIBGI),Hospital Universitari de Girona Dr. Josep Trueta,University of Girona,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN) (author)
  • Boehl, JuergenBoehringer Ingelheim GmbH (author)
  • Fink, KatharinaGerman Center for Diabetes Research (author)
  • van Greevenbroek, Marleen M.J.Maastricht University Medical Centre (author)
  • Kavousi, MaryamErasmus University Medical Center (author)
  • Minten, MichielMaastricht University (author)
  • Prinz, NicoleGerman Center for Diabetes Research (author)
  • Ipsen, NielsNovo Nordisk A/S (author)
  • Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-plf (author)
  • Ramos, RafaelUniversity of Girona,Erasmus University Medical Center (author)
  • Holl, Reinhard W.University of Ulm,German Center for Diabetes Research (author)
  • Horban, ScottUniversity of Dundee (author)
  • Duarte-Salles, TalitaErasmus University Medical Center (author)
  • Tran, Van Du T.Swiss Institute for Bioinformatics (SIB) (author)
  • Raverdy, Violeta (author)
  • Leal, YennyHospital Universitari de Girona Dr. Josep Trueta,CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),University of Girona,Girona Biomedical Research Institute (IDIBGI) (author)
  • Lenart, AdamNovo Nordisk A/S (author)
  • Pearson, EwanUniversity of Dundee (author)
  • Sparsø, ThomasNovo Nordisk A/S (author)
  • Giordano, Giuseppe N.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups(Swepub:lu)med-geg (author)
  • Ioannidis, VassiliosSwiss Institute for Bioinformatics (SIB) (author)
  • Soh, KengNovo Nordisk A/S (author)
  • Frayling, Timothy M.University of Geneva Medical School,University of Exeter (author)
  • Le Roux, Carel W.University College Dublin (author)
  • Ibberson, MarkSwiss Institute for Bioinformatics (SIB) (author)
  • Novo Nordisk A/SSwiss Institute for Bioinformatics (SIB) (creator_code:org_t)

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  • In:Life14:20024-3019

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