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Risk factors for po...
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Gustafson, PerLund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups
(author)
Risk factors for positive tuberculin skin test in Guinea-Bissau
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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Ovid Technologies (Wolters Kluwer Health),2007
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LIBRIS-ID:oai:lup.lub.lu.se:7517c151-f643-44ef-87a3-d8986b6135df
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https://lup.lub.lu.se/record/663625URI
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https://doi.org/10.1097/01.ede.0000259987.46912.2bDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Background: The tuberculin skin test is used for tracing of tuberculosis transmission and identifying individuals in need of prophylactic treatment. Methods: Using a case-control study design, we recruited 220 smear-positive tuberculosis cases and 223 randomly selected healthy community controls in Bissau, Guinea-Bissau, during 1999-2000. Tuberculin skin tests were performed on family members of cases and controls (n = 1059 and n = 92 1, respectively). Induration of 10 mm or greater was considered positive. Risk factors were calculated for children (< 15 years) and adults separately in multivariate logistic regression analysis. Results: The prevalence of positive tuberculin skin test was 41% in case-contacts compared with 22% in control-contacts, resulting in a prevalence ratio of 1.48 (95% confidence interval = 1.37-1.60). Positive skin tests among case-contacts increased with age for children, as well as with proximity to a case during the night, for both children and adults. A Bacille Calmette Guerin scar increased the likelihood of having a positive tuberculin skin test for adults in case households, but not in other categories of contacts. Among control-contacts the prevalence of positive skin test was associated with older age in children, history of tuberculosis in the family, and a positive tuberculin skin test of the control person. Conclusions: Risk factors for a positive tuberculin skin test among case- and control-contacts are closely related to tuberculosis exposure. Having a BCG scar did not increase the risk of positive skin test in unexposed individuals. Tuberculin skin testing remains a useful tool for diagnosing tuberculosis infection.
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Lisse, Ida
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Gomes, Victor
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Vieira, Cesaltina S.
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Lienhardt, Christian
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Nauclér, AndersLund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups(Swepub:lu)inf-ana
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Jensen, Henrik
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Aaby, Peter
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Enheten för infektionssjukdomarForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Epidemiology: Ovid Technologies (Wolters Kluwer Health)18:3, s. 340-3471531-54871044-3983
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