Search: (WFRF:(Braund Peter S.)) srt2:(2010-2014) pers:(Nelson Christopher P.) pers:(Samani Nilesh J.) >
Large-scale associa...
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
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Schunkert, Heribert (author)
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Koenig, Inke R. (author)
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Kathiresan, Sekar (author)
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show more...
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Reilly, Muredach P. (author)
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Assimes, Themistocles L. (author)
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Holm, Hilma (author)
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Preuss, Michael (author)
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Stewart, Alexandre F. R. (author)
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Barbalic, Maja (author)
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Gieger, Christian (author)
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Absher, Devin (author)
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Aherrahrou, Zouhair (author)
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Allayee, Hooman (author)
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Altshuler, David (author)
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Anand, Sonia S. (author)
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Andersen, Karl (author)
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Anderson, Jeffrey L. (author)
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Ardissino, Diego (author)
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- Ball, Stephen G. (author)
- Karolinska Institutet
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Balmforth, Anthony J. (author)
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Barnes, Timothy A. (author)
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Becker, Diane M. (author)
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Becker, Lewis C. (author)
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Berger, Klaus (author)
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Bis, Joshua C. (author)
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Boekholdt, S. Matthijs (author)
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Boerwinkle, Eric (author)
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Braund, Peter S. (author)
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Brown, Morris J. (author)
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Burnett, Mary Susan (author)
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Buysschaert, Ian (author)
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Carlquist, John F. (author)
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Chen, Li (author)
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Cichon, Sven (author)
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Codd, Veryan (author)
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Davies, Robert W. (author)
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Dedoussis, George (author)
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Dehghan, Abbas (author)
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Demissie, Serkalem (author)
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Devaney, Joseph M. (author)
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Diemert, Patrick (author)
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Do, Ron (author)
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Doering, Angela (author)
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Eifert, Sandra (author)
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El Mokhtari, Nour Eddine (author)
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Ellis, Stephen G. (author)
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Elosua, Roberto (author)
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Engert, James C. (author)
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Epstein, Stephen E. (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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Fischer, Marcus (author)
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Folsom, Aaron R. (author)
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Freyer, Jennifer (author)
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Gigante, Bruna (author)
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Girelli, Domenico (author)
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Gretarsdottir, Solveig (author)
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Gudnason, Vilmundur (author)
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Gulcher, Jeffrey R. (author)
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Halperin, Eran (author)
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Hammond, Naomi (author)
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Hazen, Stanley L. (author)
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Hofman, Albert (author)
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Horne, Benjamin D. (author)
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Illig, Thomas (author)
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Iribarren, Carlos (author)
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Jones, Gregory T. (author)
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Jukema, J. Wouter (author)
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Kaiser, Michael A. (author)
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Kaplan, Lee M. (author)
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Kastelein, John J. P. (author)
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Khaw, Kay-Tee (author)
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Knowles, Joshua W. (author)
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Kolovou, Genovefa (author)
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Kong, Augustine (author)
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Laaksonen, Reijo (author)
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Lambrechts, Diether (author)
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- Leander, Karin (author)
- Karolinska Institutet
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Lettre, Guillaume (author)
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Li, Mingyao (author)
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Lieb, Wolfgang (author)
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Loley, Christina (author)
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Lotery, Andrew J. (author)
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Mannucci, Pier M. (author)
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Maouche, Seraya (author)
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Martinelli, Nicola (author)
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McKeown, Pascal P. (author)
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Meisinger, Christa (author)
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Meitinger, Thomas (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Merlini, Pier Angelica (author)
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Mooser, Vincent (author)
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Morgan, Thomas (author)
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Muehleisen, Thomas W. (author)
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Muhlestein, Joseph B. (author)
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Muenzel, Thomas (author)
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Musunuru, Kiran (author)
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nahrstaedt, Janja (author)
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Nelson, Christopher P. (author)
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Noethen, Markus M. (author)
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Olivieri, Oliviero (author)
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Patel, Riyaz S. (author)
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Patterson, Chris C. (author)
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Peters, Annette (author)
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Peyvandi, Flora (author)
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Qu, Liming (author)
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Quyyumi, Arshed A. (author)
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Rader, Daniel J. (author)
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Rallidis, Loukianos S. (author)
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Rice, Catherine (author)
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Rosendaal, Frits R. (author)
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Rubin, Diana (author)
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Salomaa, Veikko (author)
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Sampietro, M. Lourdes (author)
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Sandhu, Manj S. (author)
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Schadt, Eric (author)
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Schaefer, Arne (author)
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Schillert, Arne (author)
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Schreiber, Stefan (author)
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Schrezenmeir, Juergen (author)
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Schwartz, Stephen M. (author)
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Siscovick, David S. (author)
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Sivananthan, Mohan (author)
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Sivapalaratnam, Suthesh (author)
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Smith, Albert (author)
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Smith, Tamara B. (author)
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Snoep, Jaapjan D. (author)
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Soranzo, Nicole (author)
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Spertus, John A. (author)
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Stark, Klaus (author)
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Stirrups, Kathy (author)
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Stoll, Monika (author)
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Tang, W. H. Wilson (author)
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Tennstedt, Stephanie (author)
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Thorgeirsson, Gudmundur (author)
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Thorleifsson, Gudmar (author)
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Tomaszewski, Maciej (author)
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Uitterlinden, Andre G. (author)
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van Rij, Andre M. (author)
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Voight, Benjamin F. (author)
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Wareham, Nick J. (author)
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Wells, George A. (author)
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Wichmann, H-Erich (author)
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Wild, Philipp S. (author)
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Willenborg, Christina (author)
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Witteman, Jaqueline C. M. (author)
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Wright, Benjamin J. (author)
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Ye, Shu (author)
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Zeller, Tanja (author)
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Ziegler, Andreas (author)
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Cambien, Francois (author)
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Goodall, Alison H. (author)
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Cupples, L. Adrienne (author)
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Quertermous, Thomas (author)
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Maerz, Winfried (author)
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Hengstenberg, Christian (author)
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Blankenberg, Stefan (author)
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Ouwehand, Willem H. (author)
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Hall, Alistair S. (author)
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Deloukas, Panos (author)
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Thompson, John R. (author)
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Stefansson, Kari (author)
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Roberts, Robert (author)
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Thorsteinsdottir, Unnur (author)
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O'Donnell, Christopher J. (author)
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McPherson, Ruth (author)
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Erdmann, Jeanette (author)
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Samani, Nilesh J. (author)
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(creator_code:org_t)
- 2011-03-06
- 2011
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:4, s. 153-333
- Related links:
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Abstract
Subject headings
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- We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Schunkert, Herib ...
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Koenig, Inke R.
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Kathiresan, Seka ...
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Reilly, Muredach ...
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Assimes, Themist ...
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Holm, Hilma
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Preuss, Michael
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Stewart, Alexand ...
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Barbalic, Maja
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Gieger, Christia ...
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Absher, Devin
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Aherrahrou, Zouh ...
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Allayee, Hooman
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Altshuler, David
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Anand, Sonia S.
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Andersen, Karl
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Anderson, Jeffre ...
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Ardissino, Diego
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Ball, Stephen G.
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Balmforth, Antho ...
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Barnes, Timothy ...
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Becker, Diane M.
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Becker, Lewis C.
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Berger, Klaus
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Bis, Joshua C.
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Boekholdt, S. Ma ...
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Boerwinkle, Eric
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Braund, Peter S.
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Brown, Morris J.
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Burnett, Mary Su ...
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Buysschaert, Ian
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Carlquist, John ...
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Chen, Li
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Cichon, Sven
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Codd, Veryan
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Davies, Robert W ...
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Dedoussis, Georg ...
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Dehghan, Abbas
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Demissie, Serkal ...
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Devaney, Joseph ...
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Diemert, Patrick
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Do, Ron
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Doering, Angela
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Eifert, Sandra
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El Mokhtari, Nou ...
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Ellis, Stephen G ...
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Elosua, Roberto
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Engert, James C.
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Epstein, Stephen ...
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de Faire, Ulf
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Fischer, Marcus
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Folsom, Aaron R.
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Freyer, Jennifer
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Gigante, Bruna
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Girelli, Domenic ...
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Gretarsdottir, S ...
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Gudnason, Vilmun ...
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Gulcher, Jeffrey ...
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Halperin, Eran
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Hammond, Naomi
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Hazen, Stanley L ...
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Hofman, Albert
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Horne, Benjamin ...
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Illig, Thomas
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Iribarren, Carlo ...
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Jones, Gregory T ...
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Jukema, J. Woute ...
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Kaiser, Michael ...
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Kaplan, Lee M.
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Kastelein, John ...
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Khaw, Kay-Tee
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Knowles, Joshua ...
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Kolovou, Genovef ...
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Kong, Augustine
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Laaksonen, Reijo
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Lambrechts, Diet ...
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Leander, Karin
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Lettre, Guillaum ...
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Li, Mingyao
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Lieb, Wolfgang
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Loley, Christina
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Lotery, Andrew J ...
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Mannucci, Pier M ...
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Maouche, Seraya
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Martinelli, Nico ...
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McKeown, Pascal ...
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Meisinger, Chris ...
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Meitinger, Thoma ...
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Melander, Olle
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Merlini, Pier An ...
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Mooser, Vincent
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Morgan, Thomas
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Muehleisen, Thom ...
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Muhlestein, Jose ...
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Muenzel, Thomas
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Musunuru, Kiran
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nahrstaedt, Janj ...
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Nelson, Christop ...
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Noethen, Markus ...
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Olivieri, Olivie ...
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Patel, Riyaz S.
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Patterson, Chris ...
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Peters, Annette
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Peyvandi, Flora
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Qu, Liming
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Quyyumi, Arshed ...
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Rader, Daniel J.
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Rallidis, Loukia ...
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Rice, Catherine
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Rosendaal, Frits ...
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Rubin, Diana
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Salomaa, Veikko
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Sampietro, M. Lo ...
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Sandhu, Manj S.
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Schadt, Eric
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Schaefer, Arne
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Schillert, Arne
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Schreiber, Stefa ...
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Schrezenmeir, Ju ...
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Schwartz, Stephe ...
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Siscovick, David ...
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Sivananthan, Moh ...
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Sivapalaratnam, ...
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Smith, Albert
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Smith, Tamara B.
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Snoep, Jaapjan D ...
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Soranzo, Nicole
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Spertus, John A.
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Stark, Klaus
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Stirrups, Kathy
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Stoll, Monika
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Tang, W. H. Wils ...
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Tennstedt, Steph ...
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Thorgeirsson, Gu ...
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Thorleifsson, Gu ...
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Tomaszewski, Mac ...
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Uitterlinden, An ...
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van Rij, Andre M ...
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Voight, Benjamin ...
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Wareham, Nick J.
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Wells, George A.
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Wichmann, H-Eric ...
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Wild, Philipp S.
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Willenborg, Chri ...
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Witteman, Jaquel ...
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Wright, Benjamin ...
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Ye, Shu
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Zeller, Tanja
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Ziegler, Andreas
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Cambien, Francoi ...
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Goodall, Alison ...
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Cupples, L. Adri ...
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Quertermous, Tho ...
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Maerz, Winfried
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Hengstenberg, Ch ...
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Blankenberg, Ste ...
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Ouwehand, Willem ...
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Hall, Alistair S ...
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Deloukas, Panos
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Thompson, John R ...
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Stefansson, Kari
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Roberts, Robert
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Thorsteinsdottir ...
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O'Donnell, Chris ...
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McPherson, Ruth
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Erdmann, Jeanett ...
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Samani, Nilesh J ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- Articles in the publication
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Nature Genetics
- By the university
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Lund University
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Karolinska Institutet