WFRF:(Maher Tyler)
Sökning: WFRF:(Maher Tyler) > Characterisation of...
- 1 av 4
- Föregående post
- Nästa post
- Till träfflistan
- Bermingham, Kate M.King's College London (författare)
Characterisation of Fasting and Postprandial NMR Metabolites : Insights from the ZOE PREDICT 1 Study
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
- 2023
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:756b3155-c9a3-4608-9909-87fce930e342
- https://lup.lub.lu.se/record/756b3155-c9a3-4608-9909-87fce930e342URI
- https://doi.org/10.3390/nu15112638DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Background: Postprandial metabolomic profiles and their inter-individual variability are not well characterised. Here, we describe postprandial metabolite changes, their correlations with fasting values and their inter- and intra-individual variability, following a standardised meal in the ZOE PREDICT 1 cohort. Methods: In the ZOE PREDICT 1 study (n = 1002 (NCT03479866)), 250 metabolites, mainly lipids, were measured by a Nightingale NMR panel in fasting and postprandial (4 and 6 h after a 3.7 MJ mixed nutrient meal, with a second 2.2 MJ mixed nutrient meal at 4 h) serum samples. For each metabolite, inter- and intra-individual variability over time was evaluated using linear mixed modelling and intraclass correlation coefficients (ICC) were calculated. Results: Postprandially, 85% (of 250 metabolites) significantly changed from fasting at 6 h (47% increased, 53% decreased; Kruskal–Wallis), with 37 measures increasing by >25% and 14 increasing by >50%. The largest changes were observed in very large lipoprotein particles and ketone bodies. Seventy-one percent of circulating metabolites were strongly correlated (Spearman’s rho >0.80) between fasting and postprandial timepoints, and 5% were weakly correlated (rho <0.50). The median ICC of the 250 metabolites was 0.91 (range 0.08–0.99). The lowest ICCs (ICC <0.40, 4% of measures) were found for glucose, pyruvate, ketone bodies (β-hydroxybutyrate, acetoacetate, acetate) and lactate. Conclusions: In this large-scale postprandial metabolomic study, circulating metabolites were highly variable between individuals following sequential mixed meals. Findings suggest that a meal challenge may yield postprandial responses divergent from fasting measures, specifically for glycolysis, essential amino acid, ketone body and lipoprotein size metabolites.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
- lipids
- lipoproteins
- nuclear magnetic resonance (NMR)
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Mazidi, MohsenKing's College London,University of Oxford (författare)
- Franks, Paul W.Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University(Swepub:lu)med-plf (författare)
- Maher, TylerKing's College London (författare)
- Valdes, Ana M.University of Nottingham (författare)
- Linenberg, InbarKing's College London (författare)
- Wolf, Jonathan (författare)
- Hadjigeorgiou, George (författare)
- Spector, Tim D.King's College London (författare)
- Menni, CristinaKing's College London (författare)
- Ordovas, Jose M.CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Madrid Institute For Advanced Studies (IMDEA) Food Institute,Jean Mayer USDA Human Nutrition Research Center on Aging (författare)
- Berry, Sarah E.King's College London (författare)
- Hall, Wendy L.King's College London (författare)
- King's College LondonUniversity of Oxford (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Nutrients15:112072-6643
Internetlänk
- 1 av 4
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Bermingham, Kate ...
- Mazidi, Mohsen
- Franks, Paul W.
- Maher, Tyler
- Valdes, Ana M.
- Linenberg, Inbar
- visa fler...
- Wolf, Jonathan
- Hadjigeorgiou, G ...
- Spector, Tim D.
- Menni, Cristina
- Ordovas, Jose M.
- Berry, Sarah E.
- Hall, Wendy L.
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Hälsovetenskap
- och Näringslära
- Artiklar i publikationen
- Nutrients
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
