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Characterisation of...
Characterisation of Fasting and Postprandial NMR Metabolites : Insights from the ZOE PREDICT 1 Study
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- Bermingham, Kate M. (author)
- King's College London
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- Mazidi, Mohsen (author)
- King's College London,University of Oxford
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
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- Maher, Tyler (author)
- King's College London
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- Valdes, Ana M. (author)
- University of Nottingham
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- Linenberg, Inbar (author)
- King's College London
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Wolf, Jonathan (author)
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Hadjigeorgiou, George (author)
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- Spector, Tim D. (author)
- King's College London
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- Menni, Cristina (author)
- King's College London
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- Ordovas, Jose M. (author)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Madrid Institute For Advanced Studies (IMDEA) Food Institute,Jean Mayer USDA Human Nutrition Research Center on Aging
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- Berry, Sarah E. (author)
- King's College London
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- Hall, Wendy L. (author)
- King's College London
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Nutrients. - 2072-6643. ; 15:11
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Abstract
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- Background: Postprandial metabolomic profiles and their inter-individual variability are not well characterised. Here, we describe postprandial metabolite changes, their correlations with fasting values and their inter- and intra-individual variability, following a standardised meal in the ZOE PREDICT 1 cohort. Methods: In the ZOE PREDICT 1 study (n = 1002 (NCT03479866)), 250 metabolites, mainly lipids, were measured by a Nightingale NMR panel in fasting and postprandial (4 and 6 h after a 3.7 MJ mixed nutrient meal, with a second 2.2 MJ mixed nutrient meal at 4 h) serum samples. For each metabolite, inter- and intra-individual variability over time was evaluated using linear mixed modelling and intraclass correlation coefficients (ICC) were calculated. Results: Postprandially, 85% (of 250 metabolites) significantly changed from fasting at 6 h (47% increased, 53% decreased; Kruskal–Wallis), with 37 measures increasing by >25% and 14 increasing by >50%. The largest changes were observed in very large lipoprotein particles and ketone bodies. Seventy-one percent of circulating metabolites were strongly correlated (Spearman’s rho >0.80) between fasting and postprandial timepoints, and 5% were weakly correlated (rho <0.50). The median ICC of the 250 metabolites was 0.91 (range 0.08–0.99). The lowest ICCs (ICC <0.40, 4% of measures) were found for glucose, pyruvate, ketone bodies (β-hydroxybutyrate, acetoacetate, acetate) and lactate. Conclusions: In this large-scale postprandial metabolomic study, circulating metabolites were highly variable between individuals following sequential mixed meals. Findings suggest that a meal challenge may yield postprandial responses divergent from fasting measures, specifically for glycolysis, essential amino acid, ketone body and lipoprotein size metabolites.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- lipids
- lipoproteins
- nuclear magnetic resonance (NMR)
Publication and Content Type
- art (subject category)
- ref (subject category)
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Nutrients
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- By the author/editor
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Bermingham, Kate ...
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Mazidi, Mohsen
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Franks, Paul W.
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Maher, Tyler
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Valdes, Ana M.
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Linenberg, Inbar
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show more...
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Wolf, Jonathan
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Hadjigeorgiou, G ...
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Spector, Tim D.
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Menni, Cristina
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Ordovas, Jose M.
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Berry, Sarah E.
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Hall, Wendy L.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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Nutrients
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Lund University