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Vascular dimorphism...
Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth
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- Nandadasa, Sumeda (author)
- Cleveland Clinic Foundation
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- Szafron, Jason M. (author)
- Yale University
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- Pathak, Vai (author)
- Case Western Reserve University
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- Murtada, Sae Il (author)
- Yale University
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- Kraft, Caroline M. (author)
- Cleveland Clinic Foundation
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- O’donnell, Anna (author)
- Cleveland Clinic Foundation
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- Norvik, Christian (author)
- Lund University,Lunds universitet,Kärlväggsbiologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Vessel Wall Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine
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- Hughes, Clare (author)
- Cardiff University
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- Caterson, Bruce (author)
- Cardiff University
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- Domowicz, Miriam S. (author)
- University of Chicago
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- Schwartz, Nancy B. (author)
- University of Chicago
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- Tran-Lundmark, Karin (author)
- Lund University,Lunds universitet,Kärlväggsbiologi,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Vessel Wall Biology,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine
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- Veigl, Martina (author)
- Case Western Reserve University
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- Sedwick, David (author)
- Case Western Reserve University
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- Philipson, Elliot H. (author)
- Cleveland Clinic Foundation
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- Humphrey, Jay D. (author)
- Yale University
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- Apte, Suneel S. (author)
- Cleveland Clinic Foundation
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(creator_code:org_t)
- 2020
- 2020
- English 30 s.
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In: eLife. - 2050-084X. ; 9
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.7...
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Abstract
Subject headings
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- The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan dynamics as a determinant of these contrasting vascular responses. The umbilical artery, but not the vein, has an inner layer enriched in the hydrated proteoglycan aggrecan, external to which lie contraction-primed smooth muscle cells (SMC). At birth, SMC contraction drives inner layer buckling and centripetal displacement to occlude the arterial lumen, a mechanism revealed by biomechanical observations and confirmed by computational analyses. This vascular dimorphism arises from spatially regulated proteoglycan expression and breakdown. Mice lacking aggrecan or the metalloprotease ADAMTS1, which degrades proteoglycans, demonstrate their opposing roles in umbilical vascular dimorphism, including effects on SMC differentiation. Umbilical vessel dimorphism is conserved in mammals, suggesting that differential proteoglycan dynamics and inner layer buckling were positively selected during evolution.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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eLife
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- By the author/editor
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Nandadasa, Sumed ...
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Szafron, Jason M ...
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Pathak, Vai
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Murtada, Sae Il
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Kraft, Caroline ...
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O’donnell, Anna
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show more...
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Norvik, Christia ...
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Hughes, Clare
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Caterson, Bruce
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Domowicz, Miriam ...
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Schwartz, Nancy ...
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Tran-Lundmark, K ...
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Veigl, Martina
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Sedwick, David
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Philipson, Ellio ...
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Humphrey, Jay D.
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Apte, Suneel S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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eLife
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Lund University