SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:lup.lub.lu.se:75b197b1-9b6a-4b6d-a980-98ce61bb9bf0"
 

Sökning: id:"swepub:oai:lup.lub.lu.se:75b197b1-9b6a-4b6d-a980-98ce61bb9bf0" > Heterogeneity of DK...

  • Jacobsen, Laura M.University of Florida (författare)

Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-01-18
  • American Diabetes Association,2022
  • 10 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:75b197b1-9b6a-4b6d-a980-98ce61bb9bf0
  • https://lup.lub.lu.se/record/75b197b1-9b6a-4b6d-a980-98ce61bb9bf0URI
  • https://doi.org/10.2337/dc21-0422DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • OBJECTIVE The Environmental Determinants of Diabetes in the Young (TEDDY) study is uniquely capable of investigating age-specific differences associated with type 1 diabetes. Because age is a primary driver of heterogeneity in type 1 diabetes, we sought to characterize by age metabolic derangements prior to diagnosis and clinical features associated with diabetic ketoacidosis (DKA). RESEARCH DESIGN AND METHODS The 379 TEDDY children who developed type 1 diabetes were grouped by age at onset (0–4, 5–9, and 10–14 years; n = 142, 151, and 86, respectively) with com-parisons of autoantibody profiles, HLAs, family history of diabetes, presence of DKA, symptomatology at onset, and adherence to TEDDY protocol. Time-varying analysis compared those with oral glucose tolerance test data with TEDDY children who did not progress to diabetes. RESULTS Increasing fasting glucose (hazard ratio [HR] 1.09 [95% CI 1.04–1.14]; P = 0.0003), stimulated glucose (HR 1.50 [1.42–1.59]; P < 0.0001), fasting insulin (HR 0.89 [0.83–0.95]; P = 0.0009), and glucose-to-insulin ratio (HR 1.29 [1.16–1.43]; P < 0.0001) were associated with risk of progression to type 1 diabetes. Younger children had fewer autoantibodies with more symptoms at diagnosis. Twenty-three children (6.1%) had DKA at onset, only 1 (0.97%) of 103 with and 22 (8.0%) of 276 children without a first-degree relative (FDR) with type 1 diabetes (P = 0.008). Children with DKA were more likely to be nonadherent to study protocol (P = 0.047), with longer duration between their last TEDDY evaluation and diagnosis (median 10.2 vs. 2.0 months without DKA; P < 0.001). CONCLUSIONS DKA at onset in TEDDY is uncommon, especially for FDRs. For those without familial risk, metabolic monitoring continues to provide a primary benefit of reduced DKA but requires regular follow-up. Clinical and laboratory features vary by age at onset, adding to the heterogeneity of type 1 diabetes.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Vehik, KendraUniversity of South Florida (författare)
  • Veijola, RiittaOulu University Hospital,University of Oulu (författare)
  • Warncke, KatharinaHelmholtz Zentrum München (författare)
  • Toppari, JormaTurku University Hospital,University of Turku (författare)
  • Steck, Andrea K.University of Colorado School of Medicine (författare)
  • Gesualdo, PatriciaUniversity of Colorado School of Medicine (författare)
  • Akolkar, BeenaNational Institute of Diabetes and Digestive and Kidney Diseases (författare)
  • Lundgren, MarkusLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-mn2 (författare)
  • Hagopian, William A.Pacific Northwest Research Institute (författare)
  • She, Jin XiongMedical College of Georgia (författare)
  • Rewers, MarianUniversity of Colorado School of Medicine (författare)
  • Ziegler, Anette G.University of Oulu,Oulu University Hospital (författare)
  • Krischer, Jeffrey P.University of South Florida (författare)
  • Larsson, Helena EldingLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-hla (författare)
  • Haller, Michael J.University of Florida (författare)
  • University of FloridaUniversity of South Florida (creator_code:org_t)
  • TEDDY Study Group

Sammanhörande titlar

  • Ingår i:Diabetes Care: American Diabetes Association45:3, s. 624-6330149-5992

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy