Sökning: id:"swepub:oai:lup.lub.lu.se:75b197b1-9b6a-4b6d-a980-98ce61bb9bf0" >
Heterogeneity of DK...
-
Jacobsen, Laura M.University of Florida
(författare)
Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
-
2022-01-18
-
American Diabetes Association,2022
-
10 s.
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:75b197b1-9b6a-4b6d-a980-98ce61bb9bf0
-
https://lup.lub.lu.se/record/75b197b1-9b6a-4b6d-a980-98ce61bb9bf0URI
-
https://doi.org/10.2337/dc21-0422DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
OBJECTIVE The Environmental Determinants of Diabetes in the Young (TEDDY) study is uniquely capable of investigating age-specific differences associated with type 1 diabetes. Because age is a primary driver of heterogeneity in type 1 diabetes, we sought to characterize by age metabolic derangements prior to diagnosis and clinical features associated with diabetic ketoacidosis (DKA). RESEARCH DESIGN AND METHODS The 379 TEDDY children who developed type 1 diabetes were grouped by age at onset (0–4, 5–9, and 10–14 years; n = 142, 151, and 86, respectively) with com-parisons of autoantibody profiles, HLAs, family history of diabetes, presence of DKA, symptomatology at onset, and adherence to TEDDY protocol. Time-varying analysis compared those with oral glucose tolerance test data with TEDDY children who did not progress to diabetes. RESULTS Increasing fasting glucose (hazard ratio [HR] 1.09 [95% CI 1.04–1.14]; P = 0.0003), stimulated glucose (HR 1.50 [1.42–1.59]; P < 0.0001), fasting insulin (HR 0.89 [0.83–0.95]; P = 0.0009), and glucose-to-insulin ratio (HR 1.29 [1.16–1.43]; P < 0.0001) were associated with risk of progression to type 1 diabetes. Younger children had fewer autoantibodies with more symptoms at diagnosis. Twenty-three children (6.1%) had DKA at onset, only 1 (0.97%) of 103 with and 22 (8.0%) of 276 children without a first-degree relative (FDR) with type 1 diabetes (P = 0.008). Children with DKA were more likely to be nonadherent to study protocol (P = 0.047), with longer duration between their last TEDDY evaluation and diagnosis (median 10.2 vs. 2.0 months without DKA; P < 0.001). CONCLUSIONS DKA at onset in TEDDY is uncommon, especially for FDRs. For those without familial risk, metabolic monitoring continues to provide a primary benefit of reduced DKA but requires regular follow-up. Clinical and laboratory features vary by age at onset, adding to the heterogeneity of type 1 diabetes.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Vehik, KendraUniversity of South Florida
(författare)
-
Veijola, RiittaOulu University Hospital,University of Oulu
(författare)
-
Warncke, KatharinaHelmholtz Zentrum München
(författare)
-
Toppari, JormaTurku University Hospital,University of Turku
(författare)
-
Steck, Andrea K.University of Colorado School of Medicine
(författare)
-
Gesualdo, PatriciaUniversity of Colorado School of Medicine
(författare)
-
Akolkar, BeenaNational Institute of Diabetes and Digestive and Kidney Diseases
(författare)
-
Lundgren, MarkusLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-mn2
(författare)
-
Hagopian, William A.Pacific Northwest Research Institute
(författare)
-
She, Jin XiongMedical College of Georgia
(författare)
-
Rewers, MarianUniversity of Colorado School of Medicine
(författare)
-
Ziegler, Anette G.University of Oulu,Oulu University Hospital
(författare)
-
Krischer, Jeffrey P.University of South Florida
(författare)
-
Larsson, Helena EldingLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-hla
(författare)
-
Haller, Michael J.University of Florida
(författare)
-
University of FloridaUniversity of South Florida
(creator_code:org_t)
-
TEDDY Study Group
Sammanhörande titlar
-
Ingår i:Diabetes Care: American Diabetes Association45:3, s. 624-6330149-5992
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jacobsen, Laura ...
-
Vehik, Kendra
-
Veijola, Riitta
-
Warncke, Kathari ...
-
Toppari, Jorma
-
Steck, Andrea K.
-
visa fler...
-
Gesualdo, Patric ...
-
Akolkar, Beena
-
Lundgren, Markus
-
Hagopian, Willia ...
-
She, Jin Xiong
-
Rewers, Marian
-
Ziegler, Anette ...
-
Krischer, Jeffre ...
-
Larsson, Helena ...
-
Haller, Michael ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetes Care
- Av lärosätet
-
Lunds universitet