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  • Andersen, GormLund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science (author)

Catabolism of pyrimidines in yeast: A tool to understand degradation of anticancer drugs

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Informa UK Limited,2006

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:75b89518-c953-4703-a336-126949ed46d3
  • https://lup.lub.lu.se/record/376847URI
  • https://doi.org/10.1080/15257770600889386DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-214436URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1955795URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • The pyrimidine catabolic pathway is of crucial importance in cancer patients because it is involved in degradation of several chemotherapeutic drugs, such as 5-fluorouracil; it also is important in plants, unicellular eukaryotes, and bacteria for the degradation of pyrimidine-based biocides/antibiotics. During the last decade we have developed a yeast species, Saccharomyces kluyveri, as a model and tool to study the genes and enzymes of the pyrimidine catabolic pathway. In this report, we studied degradation of uracil and its putative degradation products in 38 yeasts and showed that this pathway was present in the ancient yeasts but was lost approximately 100 million years ago in the S. cerevisiae lineage.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Merico, A. (author)
  • Björnberg, OlofLund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science(Swepub:lu)biok-obj (author)
  • Andersen, BirgitLund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science(Swepub:lu)cob-ban (author)
  • Dobritzsch, Doreen,1972-Karolinska Institutet(Swepub:uu)dordo526 (author)
  • Dobritzsch, D. (author)
  • Piskur, JureLund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science(Swepub:lu)cob-jpi (author)
  • Compagno, C. (author)
  • Biologiska institutionenNaturvetenskapliga fakulteten (creator_code:org_t)

Related titles

  • In:Nucleosides, Nucleotides & Nucleic Acids: Informa UK Limited25:9-11, s. 991-9961525-77701532-2335

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