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  • Villa, Luisa L. (author)

Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Elsevier BV,2006

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:760c5f58-3cdd-455f-a504-505620edefd2
  • https://lup.lub.lu.se/record/402450URI
  • https://doi.org/10.1016/j.vaccine.2006.04.068DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1944812URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Human papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naive and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were similar to 12- to 26-fold higher than those observed in baseline-naive women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported. (c) 2006 Elsevier Ltd. All rights reserved.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ault, Kevin A. (author)
  • Giuliano, Anna R. (author)
  • Costa, Ronaldo L. R. (author)
  • Petta, Carlos A. (author)
  • Andrade, Rosires P. (author)
  • Brown, Darron R. (author)
  • Ferenczy, Alex (author)
  • Harper, Diane M. (author)
  • Koutsky, Laura A. (author)
  • Kurman, Robert J. (author)
  • Lehtinen, Matti (author)
  • Malm, Christian (author)
  • Olsson, Sven-EricKarolinska Institutet (author)
  • Ronnett, Brigitte M. (author)
  • Skjeldestad, Finn Egil (author)
  • Steinwall, MargaretaLund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups(Swepub:lu)gyn-mst (author)
  • Stoler, Mark H. (author)
  • Wheeler, Cosette M. (author)
  • Taddeo, Frank J. (author)
  • Yu, Jimmy (author)
  • Lupinacci, Lisa (author)
  • Railkar, Radha (author)
  • Marchese, Rocio (author)
  • Esser, Mark T. (author)
  • Bryan, Janine (author)
  • Jansen, Kathrin U. (author)
  • Sings, Heather L. (author)
  • Tamms, Gretchen M. (author)
  • Saah, Alfred J. (author)
  • Barr, Eliav (author)
  • Karolinska InstitutetUrogynekologi och reproduktionsfarmakologi (creator_code:org_t)

Related titles

  • In:Vaccine: Elsevier BV24:27-28, s. 5571-55831873-25180264-410X

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  • Vaccine (Search for host publication in LIBRIS)

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