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  • Kvarnbrink, SamuelUmeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, S-90187 Umea, Sweden. (author)

LRIG1 is a prognostic biomarker in non-small cell lung cancer

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • Taylor & Francis,2015

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:76191b44-a29c-4a9d-8971-cece5f92ad79
  • https://lup.lub.lu.se/record/8074158URI
  • https://doi.org/10.3109/0284186X.2015.1021427DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-109961URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264681URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background. The leucine-rich repeats and immunoglobulin-like domains (LRIG) family of transmembrane proteins are involved in the regulation of cellular signal transduction. LRIG1 is an endogenous inhibitor of receptor tyrosine kinases (RTKs) and an emerging tumor suppressor. In the lung epithelium, the expression of LRIG1 is downregulated by tobacco smoking, and further downregulated in lung squamous cell carcinoma. Material and methods. The expression of LRIG proteins were analyzed in 347 cases of non-small cell lung cancer (NSCLC) by immunohistochemistry, and LRIG1 mRNA expression was evaluated in 807 lung cancer samples in silico in the Oncomine database. Potential associations between the expression data and the clinical parameters, including patient survival, were investigated. Results. Expression of the LRIG1 protein was found to be an independent prognostic factor in NSCLC, whereas expression of LRIG2 or LRIG3 did not correlate with patient survival. The levels of LRIG1 mRNA also correlated with the survival of NSCLC patients. Conclusion. These findings demonstrate that LRIG1 is an independent prognostic factor in patients with NSCLC that could be important in future decision-making algorithms for adjuvant lung cancer treatment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Karlsson, Terese,1979-Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, S-90187 Umea, Sweden.(Swepub:umu)teekan98 (author)
  • Edlund, KarolinaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)kaedl086 (author)
  • Botling, JohanUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)johanbot (author)
  • Lindquist, DavidUmeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, S-90187 Umea, Sweden.(Swepub:umu)dali0066 (author)
  • Jirström, KarinLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Div Pathol, Dept Clin Sci, Lund, Sweden.(Swepub:lu)pat-kji (author)
  • Micke, PatrickUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)patmi676 (author)
  • Henriksson, RogerUmeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, S-90187 Umea, Sweden.(Swepub:umu)rohe0003 (author)
  • Johansson, MikaelUmeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, S-90187 Umea, Sweden.(Swepub:umu)mijo0025 (author)
  • Hedman, HåkanUmeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, S-90187 Umea, Sweden.(Swepub:umu)hahe0001 (author)
  • Umeå universitetOnkologi (creator_code:org_t)

Related titles

  • In:Acta Oncologica: Taylor & Francis54:8, s. 1113-11191651-226X0284-186X

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