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Genetic factors aff...
Genetic factors affect the susceptibility to bacterial infections in diabetes
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- Simonsen, Johan R (author)
- University of Helsinki
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- Käräjämäki, Annemari (author)
- Vaasa Central Hospital
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- Antikainen, Anni A (author)
- University of Helsinki
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Toppila, Iiro (author)
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Prasad, Rashmi (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Mansour-Aly, Dina (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Harjutsalo, Valma (author)
- Helsinki University Central Hospital
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- Järvinen, Asko (author)
- Helsinki University Central Hospital
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- Tuomi, Tiinamaija (author)
- Institute for Molecular Medicine Finland (FIMM),Helsinki University Central Hospital,Vaasa Health Care Center,University of Helsinki
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Institute for Molecular Medicine Finland (FIMM)
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Forsblom, Carol (author)
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- Groop, Per-Henrik (author)
- Monash University
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Sandholm, Niina (author)
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- Lehto, Markku (author)
- Helsinki University Central Hospital,University of Helsinki
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(creator_code:org_t)
- 2021-05-04
- 2021
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11
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Abstract
Subject headings
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- Diabetes increases the risk of bacterial infections. We investigated whether common genetic variants associate with infection susceptibility in Finnish diabetic individuals. We performed genome-wide association studies and pathway analysis for bacterial infection frequency in Finnish adult diabetic individuals (FinnDiane Study; N = 5092, Diabetes Registry Vaasa; N = 4247) using national register data on antibiotic prescription purchases. Replication analyses were performed in a Swedish diabetic population (ANDIS; N = 9602) and in a Finnish non-diabetic population (FinnGen; N = 159,166). Genome-wide data indicated moderate but significant narrow-sense heritability for infection susceptibility (h2 = 16%, P = 0.02). Variants on chromosome 2 were associated with reduced infection susceptibility (rs62192851, P = 2.23 × 10-7). Homozygotic carriers of the rs62192851 effect allele (N = 44) had a 37% lower median annual antibiotic purchase rate, compared to homozygotic carriers of the reference allele (N = 4231): 0.38 [IQR 0.22-0.90] and 0.60 [0.30-1.20] respectively, P = 0.01). Variants rs6727834 and rs10188087, in linkage disequilibrium with rs62192851, replicated in the FinnGen-cohort (P < 0.05), but no variants replicated in the ANDIS-cohort. Pathway analysis suggested the IRAK1 mediated NF-κB activation through IKK complex recruitment-pathway to be a mediator of the phenotype. Common genetic variants on chromosome 2 may associate with reduced risk of bacterial infections in Finnish individuals with diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- ANDIS
- diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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Simonsen, Johan ...
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Käräjämäki, Anne ...
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Antikainen, Anni ...
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Toppila, Iiro
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Ahlqvist, Emma
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Prasad, Rashmi
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Mansour-Aly, Din ...
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Harjutsalo, Valm ...
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Järvinen, Asko
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Tuomi, Tiinamaij ...
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Groop, Leif
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Forsblom, Carol
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Groop, Per-Henri ...
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Sandholm, Niina
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Lehto, Markku
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MEDICAL AND HEAL ...
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