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Antimicrobial resis...
Antimicrobial resistance surveillance of Bacteroides fragilis isolated from blood cultures, Europe, 2022 (ReSuBacfrag)
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- Buhl, Michael E.J. (author)
- Paracelsus Medical University
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- Sunnerhagen, Torgny (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne
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- Join-Lambert, Olivier (author)
- University Hospital Of Caen
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- Morris, Trefor (author)
- University Hospital of Wales
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- Jeverica, Samo (author)
- Slovenian National Laboratory of Health, Environment and Food
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- Assous, Marc V. (author)
- Hebrew University of Jerusalem
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- Toprak, Nurver U. (author)
- Marmara University Hospital
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- Alcalá-Hernandez, Luis (author)
- Hospital Gregorio Maranon
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- Lienhard, Reto (author)
- ADMed Microbiologie
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- Veloo, Alida C.M. (author)
- University Medical Center Groningen
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- Cruz, Hugo (author)
- S. António General Hospital
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- Sóki, József (author)
- University of Szeged
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- Novak, Anita (author)
- University Hospital of Split
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- Mazzariol, Annarita (author)
- University of Verona
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- Wybo, Ingrid (author)
- Vrije Universiteit Brussel (VUB)
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- Dumont, Yann (author)
- University Hospital of Nancy
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- Justesen, Ulrik s. (author)
- Odense University Hospital
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(creator_code:org_t)
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- English 17 s.
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In: International Journal of Antimicrobial Agents. - 1872-7913.
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Abstract
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- BackgroundBacteroides fragilis is the most frequent cause of anaerobic bacteraemia. Although recent data suggest a rise in antimicrobial resistance (AMR) of this and other anaerobic bacteria, surveillance remains limited due to a lack of both data availability and comparability. However, a newly introduced standardised method for antimicrobial susceptibility testing (AST) of anaerobic bacteria has made larger scale surveillance possible for the first time.AimTo investigate phenotypic AMR of Bacteroides fragilis isolates from bacteraemia across Europe in 2022.MethodsIn a multicentre approach, clinical microbiology laboratories in Europe were invited to contribute results of AST for Bacteroides fragilis blood culture isolates (including only the first isolate per patient and year). AST of a selection of four antibiotics was performed locally by participating laboratories in a prospective or retrospective manner, using the new EUCAST disc diffusion method on fastidious anaerobe agar (FAA-HB).ResultsA total of 16 European countries reported antimicrobial susceptibilities in 449 unique isolates of Bacteroides fragilis from blood cultures in 2022. Clindamycin demonstrated the highest resistance rates (20.9%, range 0 - 63.6%), followed by piperacillin-tazobactam (11.1%, 0 - 54.5%), meropenem (13.4%, 0 - 45.5%), and metronidazole (1.8%, 0 - 20.0%), all with wide variation between countries.ConclusionConsidering that the mean resistance rates across Europe were higher than expected for three of the four anti-anaerobic antibiotics under surveillance, both local AST of clinically relevant isolates of Bacteroides fragilis and continued surveillance on an international level is warranted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Antimicrobial resistance surveillance
- Resistance rate
- Bacteroides fragilis
- Anaerobic bacteraemia
- invasive isolates
- Bloodstream infection
Publication and Content Type
- art (subject category)
- ref (subject category)
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Buhl, Michael E. ...
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Sunnerhagen, Tor ...
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Join-Lambert, Ol ...
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Morris, Trefor
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Jeverica, Samo
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Assous, Marc V.
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Toprak, Nurver U ...
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Alcalá-Hernandez ...
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Lienhard, Reto
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Veloo, Alida C.M ...
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Cruz, Hugo
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Sóki, József
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Novak, Anita
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Mazzariol, Annar ...
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Wybo, Ingrid
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Dumont, Yann
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Justesen, Ulrik ...
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